Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 16 findings · 2 reviews

No studies found 1 · 6.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 12.5%Moderate 13 · 81.3%High 0 · 0%

MAL‐PDT vs red light only

Investigator's global assessment (IGA) of improvement Treatment 'success' as defined by IGA score decrease5 · Moderate and severe acne vulgaris

MAL‐PDT probably leads to higher investigator's global assessment (IGA) of improvement Treatment… compared with red light only (moderate certainty).

1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    RR 1.74 [1.11, 2.74]
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Paticipant's global assessment of improvement ‐ Not measured · Moderate and severe acne vulgaris

The review found no eligible studies for this question.

1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

MAL‐PDT vs red light only

Investigator‐assessed change in inflamed lesions (ILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed change in non‐inflamed lesions (NILs) Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed percentage change in ILs Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed percentage change in NILs Lesion counts · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

MAL‐PDT vs red light only

Investigator‐assessed severe adverse effects Application site blister · Moderate and severe acne vulgaris
1 finding from 1 review
  • Light therapies for acne 2016 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 360 participants
    Moderate

Imiquimod vs MAL‐PDT

Recurrence · adults with basal cell carcinoma of the skin

Imiquimod cream probably leads to lower recurrence at 3 years compared with MAL‐PDT (moderate certainty).

2 findings from 1 review

Imiquimod vs MAL‐PDT

Cosmesis · adults with basal cell carcinoma of the skin

Imiquimod cream showed no clear difference in cosmetic outcome (excellent/good) compared with MAL‐PDT (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Number of patients with moderate/severe pain (1 hour postoperatively) · adults with basal cell carcinoma of the skin

Imiquimod cream probably leads to lower pain (moderate/severe) compared with MAL‐PDT (moderate certainty).

1 finding from 1 review

Imiquimod vs MAL‐PDT

Early treatment failure · adults with basal cell carcinoma of the skin

Imiquimod cream showed no clear difference in early treatment failure compared with MAL‐PDT (moderate certainty).

1 finding from 1 review