Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

44 questions · 44 findings · 12 reviews · Gynaecology and Fertility · Headline outcomes only

No studies found 1 · 2.3%GRADE not reported 2 · 4.5%Very low 14 · 31.8%Low 22 · 50%Moderate 5 · 11.4%High 0 · 0%

Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system

Adverse effects during treatment ‐ heaviness in lower abdomen · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin + levonorgestrel (intrauterine… changes adverse effects during treatment ‐ heaviness in lower abdomen compared with levonorgestrel intrauterine system (very low certainty).

1 finding from 1 review

Any glucocorticoid vs no glucocorticoids or placebo

Clinical pregnancy rate · assisted reproduction technology cycles

It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple: dosage and timing of… compared with no glucocorticoids or placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ Ectopic pregnancy Melatonin lower dose versus melatonin higher dose№ of participants: 120(1 RCT) · women with subfertility
1 finding from 1 review

Intervention not reported

Live birth; type of antioxidant (natural conceptions and undergoing fertility treatments) ‐ Melatonin lower dose versus melatonin higher dose№ of participants: 140(2 RCTs) · women with subfertility

The intervention showed no clear difference in live birth; type of antioxidant (natural conceptions and undergoing… (low certainty).

1 finding from 1 review

Intervention not reported

Clinical pregnancy; type of antioxidant (natural conceptions and undergoing fertility treatments) ‐ Melatonin lower dose versus melatonin higher dose№ of participants: 140(2 RCTs) · women with subfertility

The intervention showed no clear difference in clinical pregnancy; type of antioxidant (natural conceptions and… (low certainty).

1 finding from 1 review

Exercise vs no treatment

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · young women with suspected primary dysmenorrhoea
1 finding from 1 review

Exercise vs no treatment

Overall menstrual symptoms , measured by the MMDQ at the end of the intervention. Lower scores indicates lower menstrual symptom severity · young women with suspected primary dysmenorrhoea
1 finding from 1 review