Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 19 findings · 2 reviews · Airways · Headline outcomes only

No studies found 0 · 0%GRADE not reported 2 · 10.5%Very low 5 · 26.3%Low 5 · 26.3%Moderate 7 · 36.8%High 0 · 0%

Adults: higher dose/longer course vs lower dose/shorter course

Exacerbations · Adults with acute asthma

It is very uncertain whether adults: higher dose/longer course changes new exacerbation in compared with lower dose/shorter course (very low certainty).

2 findings from 1 review

Children: higher dose/longer course vs lower dose/shorter course

Exacerbations · children with acute asthma

Children: higher dose/longer course showed no clear difference in new exacerbation during compared with lower dose/shorter course (low certainty).

2 findings from 1 review

Intervention not reported

Clinical failure—primary outcome (by intention‐to‐treat analysis) · children with chronic cough of unknown origin lasting longer than 4 weeks

The intervention probably leads to lower clinical failure—primary outcome (by intention‐to‐treat analysis) (moderate certainty).

1 finding from 1 review

Intervention not reported

PC‐QOL mean score at 6 weeks PC‐QOL is a 27‐item questionnaire. Each question has a 7‐point score ranging from 1 (worst quality of life) to 7 (best quality of life). Scores for each item were added and the average taken · children with chronic cough of unknown origin lasting longer than 4 weeks

The intervention probably leads to higher PC‐QOL mean score at 6 weeks PC‐QOL is a 27‐item questionnaire. Each… (moderate certainty).

1 finding from 1 review

Intervention not reported

Duration of cough post randomisation · children with chronic cough of unknown origin lasting longer than 4 weeks

The intervention showed no clear difference in duration of cough post randomisation (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of adverse events experienced · children with chronic cough of unknown origin lasting longer than 4 weeks
1 finding from 1 review

Intervention not reported

Proportions of participants experiencing adverse events or complications · children with chronic cough of unknown origin lasting longer than 4 weeks
1 finding from 1 review