Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

42 questions · 52 findings · 18 reviews · Tobacco Addiction

No studies found 0 · 0%GRADE not reported 2 · 3.8%Very low 13 · 25%Low 13 · 25%Moderate 14 · 26.9%High 10 · 19.2%

Longer vs shorter duration of combination nicotine replacement therapy

Smoking cessation ‐ 16 weeks versus 8 weeks · people who smoke

It is very uncertain whether longer changes smoking cessation ‐ 16 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).

1 finding from 1 review

Longer vs shorter duration of combination nicotine replacement therapy

SAEs · people who smoke

It is very uncertain whether longer changes overall SAEs ‐ 26 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).

3 findings from 1 review

Smoking cessation advice vs no smoking cessation counselling, grouped by intensity of intervention

Quit at longest · individuals who smoke cigarettes and are admitted to a hospital for medical or surgical care

It is very uncertain whether smoking cessation counselling changes quit at longest compared with no smoking cessation counselling, grouped by intensity of intervention (very low certainty).

4 findings from 1 review
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Pharmacotherapy plus counselling vs no pharmacotherapy or placebo plus counselling

Quit at longest · smoking cessation in hospitalised patients

Pharmacotherapy plus counselling leads to higher quit at longest compared with no pharmacotherapy or placebo plus counselling (high certainty).

3 findings from 1 review

Intervention not reported

Face‐to‐face behavioral intervention vs minimal or no support (Measured 3 to 6 months with CO‐validated prolonged and continuous abstinence, and self‐reported abstinence) · people who use waterpipe

The intervention may leads to higher face‐to‐face behavioral intervention vs minimal or no support… (low certainty).

1 finding from 1 review

Varenicline vs e‐cigarettes

Smoking abstinence at longest · people who continued to smoke tobacco following acute coronary syndrome

It is very uncertain whether varenicline changes smoking abstinence at longest compared with e‐cigarettes (very low certainty).

1 finding from 1 review

Intervention not reported

Smoking abstinence at longest · People who smoke or who have recently quit

The intervention showed no clear difference in smoking abstinence at longest (low certainty).

1 finding from 1 review

Intervention not reported

Relapse prevention at longest · People who smoke or who have recently quit

It is very uncertain whether the intervention changes relapse prevention at longest (very low certainty).

1 finding from 1 review