Findings

What do systematic reviews say?

4 questions · 7 findings · 1 reviews · Periodontology

No studies found 0 · 0%GRADE not reported 7 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis

Levofloxacin + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -1.38 [-3.30, 0.54]
2 studies · 131 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -0.93 [-2.88, 1.02]
2 studies · 131 participants
GRADE not reported

Probing pocket depth · Adults with chronic periodontitis

Levofloxacin + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -1.23 [-1.46, -1.00]
2 studies · 131 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -1.09 [-1.33, -0.85]
2 studies · 131 participants
GRADE not reported

Adverse events · Adults with chronic periodontitis

Levofloxacin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Both included trials (Pradeep 2014; Pradeep 2015) reported dizziness and diarrhoea in the levofloxacin + SRP group.
2 studies
GRADE not reported

Clinical attachment level (CAL) · Adults with chronic periodontitis

Levofloxacin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.

2 findings from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Short-term (≤ 3 months)
MD -1.02 [-1.39, -0.65]
2 studies · 131 participants
GRADE not reported
Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Intermediate-term (> 3 months to < 1 year)
MD -1.25 [-1.51, -0.99]
2 studies · 131 participants
GRADE not reported