Findings

What do systematic reviews say?

12 questions · 13 findings · 2 reviews · Airways · Headline outcomes only

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No studies found 3 · 23.1%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 7.7%Moderate 8 · 61.5%High 1 · 7.7%

Leukotriene receptor antagonist vs usual care

Exacerbations · autumn asthma exacerbations in children

The review found no eligible studies for this question.

2 findings from 1 review

Interventions for autumn exacerbations of asthma in children 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Interventions for autumn exacerbations of asthma in children 2018 · Cochrane Headline outcomes only
OR 0.5 [0.17, 1.46]
2 studies · 1326 participants
Low

Leukotriene receptor antagonist vs usual care

Adverse events · autumn asthma exacerbations in children

Leukotriene receptor antagonist showed no clear difference in adverse events compared with usual care (high certainty).

1 finding from 1 review

Interventions for autumn exacerbations of asthma in children 2018 · Cochrane Headline outcomes only
OR 0.91 [0.63, 1.32]
2 studies · 1326 participants
High

Maintenance LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 1.2 [0.7, 2.06]
1 study · 347 participants
Moderate

Intermittent LTRA vs placebo

Serious adverse events · episodic viral wheeze in children

The review found no eligible studies for this question.

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Maintenance LTRA vs placebo

Number of participants experiencing one or more episodes requiring ED visit · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 0.66 [0.37, 1.2]
1 study · 347 participants
Moderate

Maintenance LTRA vs placebo

Number of participants experiencing one or more episodes requiring hospital admission · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 0.65 [0.23, 1.87]
1 study · 347 participants
Moderate

Maintenance LTRA vs placebo

Total number of withdrawals · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in withdrawals ‐ Total number of withdrawals compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 0.87 [0.66, 1.13]
2 studies · 1729 participants
Moderate

Maintenance LTRA vs placebo

Serious adverse events · episodic viral wheeze in children

The review found no eligible studies for this question.

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intermittent LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
RR 0.85 [0.64, 1.14]
2 studies · 343 participants
Moderate

Intermittent LTRA vs placebo

Number of participants experiencing one or more episodes requiring ED visit · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 1 [0.49, 2.02]
1 study · 141 participants
Moderate

Intermittent LTRA vs placebo

Number of participants experiencing one or more episodes requiring hospital admission · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 0.73 [0.2, 2.73]
1 study · 141 participants
Moderate

Intermittent LTRA vs placebo

Total number of withdrawals · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in withdrawals ‐ Total number of withdrawals compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 1.03 [0.79, 1.35]
2 studies · 1402 participants
Moderate