Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Pain, Palliative and Supportive Care

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

Rescue free laxation within 4 hours · patients with the management of opioid‐induced constipation in palliative care patients

Methylnaltrexone probably leads to higher rescue free laxation within 4 hours compared with placebo (moderate certainty).

1 finding from 1 review

Laxatives or methylnaltrexone for the management of constipation in palliative care patients 2011 · Cochrane Headline outcomes only
OR 6.95 [3.83, 12.61]
2 studies · 287 participants
Moderate

Rescue free laxation within 24 hours · patients with the management of opioid‐induced constipation in palliative care patients

Methylnaltrexone probably leads to higher rescue free laxation within 24 hours compared with placebo (moderate certainty).

1 finding from 1 review

Laxatives or methylnaltrexone for the management of constipation in palliative care patients 2011 · Cochrane Headline outcomes only
OR 5.42 [3.12, 9.41]
2 studies · 287 participants
Moderate