Isoniazid prophylaxis may leads to lower active TB compared with placebo (low certainty).
Isoniazid prophylaxis may leads to lower death compared with placebo (low certainty).
It is very uncertain whether isoniazid prophylaxis changes active TB compared with placebo (very low certainty).
It is very uncertain whether isoniazid prophylaxis changes death compared with placebo (very low certainty).
The intervention showed no clear difference in incidence of pulmonary tuberculosis in children with HIV infection ‐… (moderate certainty).
The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).
The intervention showed no clear difference in incidence of adverse events ‐ isoniazid prophylaxis only (moderate certainty).
Isoniazid probably leads to lower tuberculosis compared with no treatment (moderate certainty).
Isoniazid probably leads to higher INH hepatotoxicity Jaundice, elevated bilirubin, elevated liver… compared with no treatment (moderate certainty).
Isoniazid showed no clear difference in all‐cause mortality compared with no treatment (low certainty).