Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

20 questions · 24 findings · 4 reviews · Wounds

No studies found 8 · 33.3%GRADE not reported 0 · 0%Very low 10 · 41.7%Low 5 · 20.8%Moderate 1 · 4.2%High 0 · 0%

Iodine vs non‐antibacterial

Wound healing · people with burns

Iodine may leads to lower wound healing (number of healing events): iodophor versus hydrogel compared with non‐antibacterial (low certainty).

3 findings from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.17 [0.08, 0.34]
    1 study · 120 participants
    Low
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    MD 5.38 [3.09, 7.67]
    1 study · 277 participants
    Very low
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 55 participants
    Very low

Iodine vs non‐antibacterial

Infection: iodine gauze versus MEBO · people with burns

Iodine showed no clear difference in infection: iodine gauze versus MEBO compared with non‐antibacterial (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.3 [0.47, 3.61]
    1 study · 211 participants
    Low

Iodine vs non‐antibacterial

Adverse effects: iodine gauze versus MEBO · people with burns

Iodine showed no clear difference in adverse effects: iodine gauze versus MEBO compared with non‐antibacterial (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.71 [0.3, 1.69]
    1 study · 211 participants
    Low

Iodine vs topical antibiotics

Wound healing · people with burns

It is very uncertain whether iodine changes wound healing (mean time to healing) compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 148 participants
    Very low

Iodine vs topical antibiotics

Infection · people with burns

The review found no eligible studies for this question.

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Iodine vs topical antibiotics

Adverse events · people with burns

It is very uncertain whether iodine changes adverse events compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.86 [0.35, 2.1]
    1 study · 40 participants
    Very low

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ overall comparison between chlorhexidine and povidone‐iodine (during in‐patient stay) · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ overall comparison between chlorhexidine and… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ subgroup: chlorhexidine in aqueous solution… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in aqueous solution · patients with a central venous catheter

It is very uncertain whether chlorhexidine changes catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus… compared with povidone‐iodine (very low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

Catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus povidone‐iodine in alcohol · patients with a central venous catheter

Chlorhexidine showed no clear difference in catheter‐related BSI ‐ subgroup: chlorhexidine in alcohol versus… compared with povidone‐iodine (moderate certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

All‐cause mortality ‐ Chlorhexidine in aqueous solution versus povidone‐iodine in aqueous solution Clinical assessment · patients with a central venous catheter

Chlorhexidine showed no clear difference in all‐cause mortality ‐ Chlorhexidine in aqueous solution versus… compared with povidone‐iodine (low certainty).

1 finding from 1 review

Chlorhexidine vs povidone‐iodine

All‐cause mortality ‐ Chlorhexidine in alcohol versus povidone‐iodine in aqueous solution Clinical assessment · patients with a central venous catheter

Chlorhexidine showed no clear difference in all‐cause mortality ‐ Chlorhexidine in alcohol versus… compared with povidone‐iodine (low certainty).

1 finding from 1 review

NMA evidence for individual network: proportion with complete healing ‐ interventions vs saline gauze

Iodine‐containing dressings · people with pressure ulcers

It is very uncertain whether NMA evidence for individual network: proportion with complete… changes iodine‐containing dressings compared with saline gauze (very low certainty).

1 finding from 1 review

Hydrogel dressings vs povidone‐iodine

Time to complete healing · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether hydrogel dressing changes time to wound healing (days) compared with wound cleaning with 10% povidone iodine (very low certainty).

1 finding from 1 review

Hydrogel dressings vs povidone‐iodine

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

The review found no eligible studies for this question.

3 findings from 1 review

Hydrogel dressings vs povidone‐iodine

Adverse effects (surgical site infection or allergic reaction) · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

It is very uncertain whether hydrogel dressing changes adverse effects (surgical site infection or allergic reaction) compared with wound cleaning with 10% povidone iodine (very low certainty).

1 finding from 1 review