What do systematic reviews say?

Iodine supplementation vs control

Iodine supplementation showed no clear difference in mortality before hospital discharge compared with control (high certainty).

• Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.01 [0.72, 1.42]
  2 studies · 1380 participants
  High

Iodine supplementation vs control

• Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1259 participants
  High

Iodine supplementation vs control

• Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1259 participants
  High

Iodine supplementation vs control

• Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1259 participants
  High

Iodine supplementation vs control

Iodine supplementation showed no clear difference in low score in any main Bayley domain (< 85) or death compared with control (high certainty).

• Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.05 [0.94, 1.17]
  1 study · 1259 participants
  High

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Chlorhexidine dressing following alcohol cleansing showed no clear difference in sepsis without a source compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

• Antimicrobial dressings for the prevention of catheter‐related infections in newborn infants with central venous… 2016 · Cochrane Headline outcomes only
  RR 1.06 [0.75, 1.52]
  1 study · 705 participants
  Moderate

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Chlorhexidine dressing following alcohol cleansing showed no clear difference in catheter‐related blood stream infection compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

• Antimicrobial dressings for the prevention of catheter‐related infections in newborn infants with central venous… 2016 · Cochrane Headline outcomes only
  RR 1.18 [0.53, 2.65]
  1 study · 655 participants
  Moderate

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Chlorhexidine dressing following alcohol cleansing probably leads to lower catheter colonisation compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

• Antimicrobial dressings for the prevention of catheter‐related infections in newborn infants with central venous… 2016 · Cochrane Headline outcomes only
  RR 0.62 [0.45, 0.86]
  1 study · 655 participants
  Moderate

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Chlorhexidine dressing following alcohol cleansing probably leads to higher adverse effects: contact dermatitis compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

• Antimicrobial dressings for the prevention of catheter‐related infections in newborn infants with central venous… 2016 · Cochrane Headline outcomes only
  RR 43.06 [2.61, 710.44]
  1 study · 670 participants
  Moderate