Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

102 questions · 106 findings · 15 reviews · Headline outcomes only

No studies found 31 · 29.2%GRADE not reported 4 · 3.8%Very low 33 · 31.1%Low 23 · 21.7%Moderate 10 · 9.4%High 5 · 4.7%

Iodine vs non‐antibacterial

Wound healing · people with burns

Iodine may leads to lower wound healing (number of healing events): iodophor versus hydrogel compared with non‐antibacterial (low certainty).

3 findings from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.17 [0.08, 0.34]
    1 study · 120 participants
    Low
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    MD 5.38 [3.09, 7.67]
    1 study · 277 participants
    Very low
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    1 study · 55 participants
    Very low

Iodine vs non‐antibacterial

Infection: iodine gauze versus MEBO · people with burns

Iodine showed no clear difference in infection: iodine gauze versus MEBO compared with non‐antibacterial (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.3 [0.47, 3.61]
    1 study · 211 participants
    Low

Iodine vs non‐antibacterial

Adverse effects: iodine gauze versus MEBO · people with burns

Iodine showed no clear difference in adverse effects: iodine gauze versus MEBO compared with non‐antibacterial (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.71 [0.3, 1.69]
    1 study · 211 participants
    Low

Fortification of salt with iron and iodine vs fortification of salt with iodine

Anaemia prevalence · participants were of any age or sex and from any country, regardless of baseline iron and iodine status

Fortification of salt with iron and iodine probably leads to lower prevalence of anaemia compared with fortification of salt with iodine (moderate certainty).

1 finding from 1 review

Fortification of salt with iron and iodine vs fortification of salt with iodine

Prevalence of iron deficiency anaemia · participants were of any age or sex and from any country, regardless of baseline iron and iodine status

Fortification of salt with iron and iodine may leads to lower prevalence of iron deficiency anaemia compared with fortification of salt with iodine (low certainty).

1 finding from 1 review

Iodine vs topical antibiotics

Wound healing · people with burns

It is very uncertain whether iodine changes wound healing (mean time to healing) compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 148 participants
    Very low

Iodine vs topical antibiotics

Infection · people with burns

The review found no eligible studies for this question.

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Iodine vs topical antibiotics

Adverse events · people with burns

It is very uncertain whether iodine changes adverse events compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.86 [0.35, 2.1]
    1 study · 40 participants
    Very low

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal hypothyroidism ‐ pregnancy · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ pregnancy compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Low birthweight · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in low birthweight compared with same supplement without iodine or no treatment/placebo (child… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal hypothyroidism or elevated TSH · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal hypothyroidism or elevated TSH compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Neonatal adverse effect: elevated TPO‐ab · women during the preconception, pregnancy and postpartum period

It is very uncertain whether any supplement containing iodine changes neonatal adverse effect: elevated TPO‐ab compared with same supplement without iodine or no treatment/placebo (child… (very low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Maternal hypothyroidism ‐ postpartum · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in maternal hypothyroidism ‐ postpartum compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review

Any supplement containing iodine vs same supplement without iodine or no treatment/placebo (maternal outcomes)

Preterm birth · women during the preconception, pregnancy and postpartum period

Any supplement containing iodine showed no clear difference in preterm birth compared with same supplement without iodine or no treatment/placebo (maternal… (low certainty).

1 finding from 1 review