Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

22 questions · 22 findings · 4 reviews · Heart · Headline outcomes only

No studies found 5 · 22.7%GRADE not reported 0 · 0%Very low 11 · 50%Low 5 · 22.7%Moderate 1 · 4.5%High 0 · 0%

IVIg vs placebo or no treatment

Event‐free survival (no death, transplant, or left ventricular assist device) ‐ adults with myocarditis · adults with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes event‐free survival (risk of death, cardiac transplant, or left… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Overall survival (risk of death) ‐ adults with myocarditis, median · adults with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes overall survival (risk of death) ‐ adults with myocarditis, median compared with placebo or no treatment (very low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Overall survival (risk of death) ‐ children with myocarditis, 6‐month · children with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes overall survival (risk of death) ‐ children with myocarditis, 6‐month compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Mortality before hospital discharge · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in all‐cause mortality (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Hospital readmission · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in readmission to hospital following discharge compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Acute kidney injury · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in acute kidney injury (adverse event) (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Cure · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

The review found no eligible studies for this question.

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Adverse events · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

Partial oral treatment showed no clear difference in adverse events compared with conventional intravenous treatment of endocarditis on the left side… (low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Congestive heart failure · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes congestive heart failure compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Need for cardiac surgical interventions · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes need for cardiac surgicalinterventions compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Septic embolism · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes septic embolism compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Uncontrolled infection · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

The review found no eligible studies for this question.

1 finding from 1 review