Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

118 questions · 119 findings · 8 reviews · HIV/AIDS

No studies found 0 · 0%GRADE not reported 5 · 4.2%Very low 20 · 16.8%Low 41 · 34.5%Moderate 49 · 41.2%High 4 · 3.4%

Structural and community‐level interventions for increasing condom use vs usual care

HIV incidence (observational studies) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HIV incidence (person/years) compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HIV prevalence · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HIV prevalence compared with standard care (low certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Herpes Simplex Virus 2 (HSV‐2) incidence (person/years) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in herpes Simplex Virus 2 (HSV‐2) incidence (person/years) compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

HSV‐2 prevalence · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in HSV‐2 prevalence compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Two or more sexual partners in last year · low and high‐risk populations

Structural and community‐level interventions for increasing condom use showed no clear difference in two or more sexual partners in last year compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Use of birth control methods (condom use at last sex) · low and high‐risk populations

Structural and community‐level interventions for increasing condom use probably leads to higher use of condom during last sexual intercourse compared with standard care (moderate certainty).

1 finding from 1 review

Structural and community‐level interventions for increasing condom use vs usual care

Knowledge: condom can prevent STIs · low and high‐risk populations

Structural and community‐level interventions for increasing condom use probably leads to higher knowledge: condom can prevent STIs compared with standard care (moderate certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission at 12 months among infants whose HIV diagnostic testing was negative within 6 weeks of birth and whose mothers were not on HAART · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission at 12 months among infants whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission at 12 months among all infants whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

Infant mortality at 12 months among all those whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in infant mortality at 12 months among all those whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission or death at 12 months among all infants whose HIV… compared with a once‐daily NVP regimen administered (moderate certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in infants with Severe Adverse Events compared with a once‐daily NVP regimen administered (high certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission at 6 months among infants whose HIV diagnostic testing was negative within 6 weeks of birth and whose mothers were not on HAART · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months may leads to lower HIV transmission at 6 months among infants whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission at 6 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months may leads to lower HIV transmission at 6 months among all infants whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

Infant mortality at 6 months among all those whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months may leads to lower infant mortality at 6 months among all those whose HIV diagnostic… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered

HIV transmission or death at 6 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers

A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission or death at 6 months among all infants whose HIV… compared with a once‐daily NVP regimen administered (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks showed no clear difference in HIV Transmission at 6 months among those whose HIV diagnostic… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Infant Mortality at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to lower infant Mortality at 6 months among those whose HIV diagnostic… compared with sdNVP (low certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

HIV Transmission or Death at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks probably leads to lower HIV Transmission or Death at 6 months among those whose HIV… compared with sdNVP (moderate certainty).

1 finding from 1 review

An extended NVP regimen administered to infants for 6 weeks vs sdNVP

Genotypic Resistance to NVP among Ugandan infants HIV‐infected at 6 weeks ViroSeq · Breastfeeding infants of HIV‐infected mothers

An extended NVP regimen administered to infants for 6 weeks may leads to higher genotypic Resistance to NVP among Ugandan infants HIV‐infected at 6… compared with sdNVP (low certainty).

1 finding from 1 review