A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered: HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth
- Population
- Breastfeeding infants of HIV‐infected mothers
- Intervention
- A once‐daily NVP regimen administered for 6 months
- Comparison
- a once‐daily NVP regimen administered
- Outcome
- HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth
A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission or death at 12 months among all infants whose HIV… compared with a once‐daily NVP regimen administered (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission or death at 12 months among all infants whose HIV… compared with a once‐daily NVP regimen administered (moderate certainty). Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane Headline outcomes only | HR 0.66 [0.42, 1.05] | 1 study · 1522 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.