What do systematic reviews say?

Skin care intervention vs standard skin care or no skin care intervention

Skin care intervention showed no clear difference in slippages (over the intervention period) compared with standard skin care or no skin care intervention (low certainty).

• Skin care interventions in infants for preventing eczema and food allergy 2022 · Cochrane Headline outcomes only
  RR 1.42 [0.67, 2.99]
  4 studies · 2538 participants
  Low

Skin care intervention vs standard skin care or no skin care intervention

Skin care intervention probably leads to higher skin infection (over the intervention period) compared with standard skin care or no skin care intervention (moderate certainty).

• Skin care interventions in infants for preventing eczema and food allergy 2022 · Cochrane Headline outcomes only
  RR 1.33 [1.01, 1.75]
  6 studies · 2728 participants
  Moderate

Skin care intervention vs standard skin care or no skin care intervention

Skin care intervention showed no clear difference in stinging/allergic reactions to moisturisers (over the intervention… compared with standard skin care or no skin care intervention (low certainty).

• Skin care interventions in infants for preventing eczema and food allergy 2022 · Cochrane Headline outcomes only
  RR 2.24 [0.67, 7.43]
  4 studies · 343 participants
  Low

Dietary interventions vs usual care

Dietary intervention showed no clear difference in adherence to the intervention compared with usual care (low certainty).

• Lifestyle changes for treating psoriasis 2019 · Cochrane Headline outcomes only
  RR 1.26 [0.76, 2.09]
  2 studies · 105 participants
  Low

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

The review found no eligible studies for this question.

• Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Skin care intervention vs standard skin care or no skin care intervention

Skin care intervention showed no clear difference in eczema diagnosis by 1 to 3 years compared with standard skin care or no skin care intervention (moderate certainty).

• Skin care interventions in infants for preventing eczema and food allergy 2022 · Cochrane Headline outcomes only
  RR 1.03 [0.81, 1.31]
  7 studies · 3075 participants
  Moderate

Skin care intervention vs standard skin care or no skin care intervention

Skin care intervention showed no clear difference in igE‐mediated food allergy (oral food challenge) by 1 to 3 years compared with standard skin care or no skin care intervention (low certainty).

• Skin care interventions in infants for preventing eczema and food allergy 2022 · Cochrane Headline outcomes only
  RR 2.53 [0.99, 6.49]
  1 study · 976 participants
  Low

Skin care intervention vs standard skin care or no skin care intervention

Skin care intervention showed no clear difference in time to onset of eczema compared with standard skin care or no skin care intervention (moderate certainty).

• Skin care interventions in infants for preventing eczema and food allergy 2022 · Cochrane Headline outcomes only
  HR 0.86 [0.65, 1.14]
  9 studies · 3349 participants
  Moderate

Skin care intervention vs standard skin care or no skin care intervention

Skin care intervention showed no clear difference in parent report of immediate reaction to common food allergen (at 2… compared with standard skin care or no skin care intervention (low certainty).

• Skin care interventions in infants for preventing eczema and food allergy 2022 · Cochrane Headline outcomes only
  RR 1.27 [1, 1.61]
  1 study · 1171 participants
  Low

Skin care intervention vs standard skin care or no skin care intervention

Skin care intervention showed no clear difference in allergic sensitisation to a food allergen (at 1 to 3 years) compared with standard skin care or no skin care intervention (low certainty).

• Skin care interventions in infants for preventing eczema and food allergy 2022 · Cochrane Headline outcomes only
  RR 1.05 [0.64, 1.71]
  3 studies · 1794 participants
  Low

Adverse event outcomes for dietary combined with physical activity interventions vs information only

Dietary intervention and exercise programme showed no clear difference in adherence to the intervention compared with information only (moderate certainty).

• Lifestyle changes for treating psoriasis 2019 · Cochrane Headline outcomes only
  RR 0.95 [0.89, 1.01]
  1 study · 303 participants
  Moderate

Any topical or systemic intervention vs Placebo, no treatment, or another intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  None of the included studies assessed the effectiveness of treatments of genital ELP; no evidence was found for genital ELP.
  0 studies
  No studies found

Any topical or systemic intervention vs Placebo, no treatment, or another intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  None of the studies involved oesophageal disease; hence, no evidence was found for the treatment of oesophageal ELP.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  None of the included studies assessed the effectiveness of treatments of genital ELP; thus, this outcome was not reported.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

The review found no eligible studies for this question.

• Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
  No studies reported this outcome.
  0 studies
  No studies found

Laser therapy vs no intervention

• Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 71 participants
  Very low

Laser therapy vs no intervention

• Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 119 participants
  Low

Dietary interventions vs usual care

Dietary intervention may leads to higher severity of psoriasis PASI 75 (the proportion of participants… compared with usual care (low certainty).

• Lifestyle changes for treating psoriasis 2019 · Cochrane Headline outcomes only
  RR 1.66 [1.07, 2.58]
  2 studies · 323 participants
  Low