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What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 3 reviews · Methodology

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No studies found 13 · 41.9%GRADE not reported 0 · 0%Very low 10 · 32.3%Low 6 · 19.4%Moderate 2 · 6.5%High 0 · 0%

Intervention not reported

Non‐serious adverse events for all placebos compared with wait‐list or no treatment (Spontaneous reporting of dichotomous outcomes) (Post‐treatment) · patients with mental health disorders

It is very uncertain whether the intervention changes non‐serious adverse events for all placebos compared with wait‐list… (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events for all placebos compared with wait‐list or no treatment (Spontaneous reporting of dichotomous outcomes) (Post‐treatment) · patients with mental health disorders

It is very uncertain whether the intervention changes serious adverse events for all placebos compared with wait‐list or… (very low certainty).

1 finding from 1 review

Risk‐based vs extensive on‐site monitoring

Combined outcome of proportion of participants with major or critical monitoring findings · clinical trials in all fields of health care

Risk‐based showed no clear difference in combined outcome of proportion of participants with major or… compared with extensive on‐site monitoring (moderate certainty).

1 finding from 1 review

Central and local monitoring only vs central and local monitoring with on‐site visits

Impact of the monitoring strategy on · clinical trials in all fields of health care

It is very uncertain whether central and local monitoring only changes impact of the monitoring strategy on compared with central and local monitoring with on‐site visits (very low certainty).

1 finding from 1 review