Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,080 questions · 1,098 findings · 35 reviews · Skin · Headline outcomes only

No studies found 401 · 36.5%GRADE not reported 41 · 3.7%Very low 183 · 16.7%Low 209 · 19%Moderate 211 · 19.2%High 53 · 4.8%

Skin care intervention vs standard skin care or no skin care intervention

Stinging/allergic reactions to moisturisers (over the intervention period) · infants

Skin care intervention showed no clear difference in stinging/allergic reactions to moisturisers (over the intervention… compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

IgE‐mediated food allergy (oral food challenge) by 1 to 3 years · infants

Skin care intervention showed no clear difference in igE‐mediated food allergy (oral food challenge) by 1 to 3 years compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

Parent report of immediate reaction to common food allergen (at 2 years) · infants

Skin care intervention showed no clear difference in parent report of immediate reaction to common food allergen (at 2… compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

Allergic sensitisation to a food allergen (at 1 to 3 years) · infants

Skin care intervention showed no clear difference in allergic sensitisation to a food allergen (at 1 to 3 years) compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Dietary interventions vs usual care

Percentage of participants reaching PASI 75 · psoriasis

Dietary intervention may leads to higher severity of psoriasis PASI 75 (the proportion of participants… compared with usual care (low certainty).

1 finding from 1 review

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants cleared or almost cleared ‐ · chronic palmoplantar pustulosis

It is very uncertain whether etretinate with PUVA therapy as co‐intervention changes proportion of participants cleared or almost cleared in the short… compared with placebo with PUVA therapy (very low certainty).

1 finding from 1 review