Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

325 questions · 325 findings · 20 reviews · Cystic Fibrosis and Genetic Disorders · Headline outcomes only

No studies found 135 · 41.5%GRADE not reported 3 · 0.9%Very low 98 · 30.2%Low 56 · 17.2%Moderate 26 · 8%High 7 · 2.2%

Psychological interventions vs usual care

Adherence to inhaled therapies cMPR · children, adolescents or adults with CF

Summary of findings: psychological interventions probably leads to higher adherence to inhaled therapies: % of prescribed inhaled therapies… compared with usual care (moderate certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) compared with usual care (low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).

1 finding from 1 review