Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

541 questions · 556 findings · 112 reviews · Headline outcomes only

No studies found 130 · 23.4%GRADE not reported 22 · 4%Very low 156 · 28.1%Low 151 · 27.2%Moderate 72 · 12.9%High 25 · 4.5%

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Patients free of RRT after discontinuing CRRT · AKI

Intensive showed no clear difference in patients free of RRT after discontinuing CRRT compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

2 findings from 1 review

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Mortality: patients with AKI related to cardiac or general surgery · patients with AKI who need CRRT

Intensive leads to lower mortality: patients with AKI related to cardiac or general surgery compared with less intensive continuous renal replacement therapy (CRRT) (high certainty).

1 finding from 1 review

Intensive vs less intensive continuous renal replacement therapy (CRRT)

Mortality: patients with AKI not related to surgery · patients with AKI who need CRRT

Intensive showed no clear difference in mortality: patients with AKI not related to surgery compared with less intensive continuous renal replacement therapy (CRRT) (low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Transplant or graft survival · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes transplant or graft survival compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Delayed graft function · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes delayed graft function Time frame: 1 to 3 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Death: unknown time frame · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes death (any cause) Time frame: 1 to 5 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

Less intensive vs more intensive follow‐up after primary cancer treatment

Depression · adult cancer survivors from the following cancer sites: breast, colorectal, head‐and‐neck, Hodgkin lymphoma, melanoma, non‐small cell lung…

The review found no eligible studies for this question.

1 finding from 1 review

Less intensive vs more intensive follow‐up after primary cancer treatment

Overall survival · adult cancer survivors from the following cancer sites: breast, colorectal, head‐and‐neck, Hodgkin lymphoma, melanoma, non‐small cell lung…

Less intensive showed no clear difference in overall survival compared with more intensive follow‐up after primary cancer treatment (low certainty).

1 finding from 1 review