What do systematic reviews say?

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy may leads to lower occurrence of CIP/CIM ‐ in total population randomised compared with conventional insulin therapy (low certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.7 [0.6, 0.82]
  2 studies · 2748 participants
  Low

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy probably leads to lower occurrence of CIP/CIM ‐ in screened population compared with conventional insulin therapy (moderate certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.65 [0.55, 0.77]
  2 studies · 825 participants
  Moderate

Intensive insulin therapy vs conventional insulin therapy

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2748 participants
  High

Intensive insulin therapy vs conventional insulin therapy

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2748 participants
  High

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy showed no clear difference in death ‐ at 30 days after ICU admission, in total population randomised compared with conventional insulin therapy (high certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.94 [0.8, 1.1]
  2 studies · 2748 participants
  High

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy showed no clear difference in death ‐ at 180 days after ICU admission, in total population… compared with conventional insulin therapy (moderate certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 0.87 [0.76, 1]
  2 studies · 2748 participants
  Moderate

Intensive insulin therapy vs conventional insulin therapy

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

• Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
  RR 6.27 [4.15, 9.49]
  2 studies · 2748 participants
  High

Corticosteroids vs control

Corticosteroid leads to higher adverse events ‐ diabetes mellitus requiring insulin compared with control (high certainty).

• Corticosteroids for Guillain‐Barré syndrome 2016 · Cochrane Headline outcomes only
  RR 2.21 [1.19, 4.12]
  2 studies · 467 participants
  High

Intervention not reported

• Recombinant human insulin‐like growth factor I (rhIGF‐I) for the treatment of amyotrophic lateral sclerosis/motor… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 690 participants
  Low

Intervention not reported

• Recombinant human insulin‐like growth factor I (rhIGF‐I) for the treatment of amyotrophic lateral sclerosis/motor… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 357 participants
  Low

Intervention not reported

• Recombinant human insulin‐like growth factor I (rhIGF‐I) for the treatment of amyotrophic lateral sclerosis/motor… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  156 participants
  Low

Intervention not reported

• Recombinant human insulin‐like growth factor I (rhIGF‐I) for the treatment of amyotrophic lateral sclerosis/motor… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 449 participants
  Low

Intervention not reported

• Recombinant human insulin‐like growth factor I (rhIGF‐I) for the treatment of amyotrophic lateral sclerosis/motor… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 779 participants
  Low