Health‐related quality of life
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
Summary of findings: insulin glargine showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).
1 finding from 1 review
All‐cause mortality
HbA1c (%)
AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation
Insulin detemir showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).
1 finding from 1 review
RR 0.88 [0.64, 1.2]
1 study · 8 participants
Moderate
Socioeconomic effects
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3) Progression in retinopathy (4) Amputations (5) ESRD
It is very uncertain whether insulin detemir changes diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3)… compared with NPH insulin (very low certainty).
1 finding from 1 review
RR 1.5 [0.68, 3.32]
1 study · 2 participants
Very low
Hypoglycaemic episodes
It is very uncertain whether insulin detemir changes hypoglycaemic episodes (1) Severe hypoglycaemia (2) Serious… compared with NPH insulin (very low certainty).
1 finding from 1 review
RR 0.45 [0.17, 1.2]
1 study · 5 participants
Very low
HbA1c (%)
All‐cause mortality
0.14 [0, 6.98]
8 studies · 2175 participants
Moderate
Peto OR 1.06 [0.62, 1.82]
14 studies · 6173 participants
Low
Diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3) Progression in retinopathy (4) Amputations (5) ESRD
It is very uncertain whether insulin glargine changes diabetes‐related complications (1) Fatal MI (2) Fatal stroke (3)… compared with NPH insulin (very low certainty).
1 finding from 1 review
RR 1.03 [0.6, 1.77]
1 study · 4 participants
Very low
Hypoglycaemic episodes
It is very uncertain whether insulin glargine changes hypoglycaemic episodes(1) Severe hypoglycaemia (2) Serious… compared with NPH insulin (very low certainty).
1 finding from 1 review
Health‐related quality of life
1 finding from 1 review
AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation
Insulin glargine showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Socioeconomic effects
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality · non‐critically ill hospitalised adults with diabetes mellitus
Sliding scale insulin showed no clear difference in all‐cause mortality (N) compared with basal‐bolus insulin (low certainty).
1 finding from 1 review
Diabetes‐related morbidity · non‐critically ill hospitalised adults with diabetes mellitus
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Severe hypoglycaemia · non‐critically ill hospitalised adults with diabetes mellitus
It is very uncertain whether sliding scale insulin changes severe hypoglycaemic episodes (N) compared with basal‐bolus insulin (very low certainty).
1 finding from 1 review
Length of hospital stay · non‐critically ill hospitalised adults with diabetes mellitus
1 finding from 1 review
Adverse events other than hypoglycaemic episodes · non‐critically ill hospitalised adults with diabetes mellitus
It is very uncertain whether sliding scale insulin changes adverse events other than hypoglycaemic episodes (postoperative… compared with basal‐bolus insulin (very low certainty).
1 finding from 1 review