Insulin glargine vs NPH insulin: Hypoglycaemic episodes
It is very uncertain whether insulin glargine changes hypoglycaemic episodes(1) Severe hypoglycaemia (2) Serious… compared with NPH insulin (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Insulin glargine vs NPH insulin Hypoglycaemic episodes(1) Severe hypoglycaemia (2) Serious hypoglycaemia (3) Confirmed hypoglycaemia (BG < 75 mg/dL) (4) Confirmed hypoglycaemia (BG < 55 mg/dL) (5) Confirmed nocturnal hypoglycaemia (BG < 75 mg/dL) (6) Confirmed nocturnal hypoglyc... It is very uncertain whether insulin glargine changes hypoglycaemic episodes(1) Severe hypoglycaemia (2) Serious… compared with NPH insulin (very low certainty). (Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2… (2020) · Cochrane Headline outcomes only | RR 0.68 [0.46, 1.01] | 1 study · 14 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| (Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.