Health‐related quality of life
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
Summary of findings: insulin glargine showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Hypertensive disorders of pregnancy: pre‐eclampsia · women with gestational diabetes mellitus
Insulin showed no clear difference in hypertensive disorders of pregnancy (pre‐eclampsia) compared with anti‐diabetic agent (moderate certainty).
1 finding from 1 review
Perinatal (fetal and neonatal death) and later infant mortality · Infants of women diagnosed with gestational diabetes
Insulin showed no clear difference in perinatal (fetal and neonatal death) and later infant mortality compared with anti‐diabetic agent (low certainty).
1 finding from 1 review
Death or serious morbidity composite · Infants of women diagnosed with gestational diabetes
Insulin showed no clear difference in death or serious morbidity composite compared with anti‐diabetic agent (moderate certainty).
1 finding from 1 review
Neonatal hypoglycaemia · Infants of women diagnosed with gestational diabetes
Insulin showed no clear difference in neonatal hypoglycaemia compared with anti‐diabetic agent (low certainty).
1 finding from 1 review
Adiposity · Infants of women diagnosed with gestational diabetes
Insulin showed no clear difference in adiposity at birth ‐ percentage fat mass compared with anti‐diabetic agent (moderate certainty).
3 findings from 1 review
no estimate extracted
1 study · 82 participants
Moderate
no estimate extracted
1 study · 82 participants
Very low
MD 0.5
1 study · 318 participants
Low
Diabetes ‐ not reported · Infants of women diagnosed with gestational diabetes
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Neurosensory disability · Infants of women diagnosed with gestational diabetes
Insulin showed no clear difference in neurosensory disability in later childhood (18 months) Mild… compared with anti‐diabetic agent (low certainty).
1 finding from 1 review
Hypertensive disorders of pregnancy · women with gestational diabetes mellitus
Insulin probably leads to higher hypertensive disorders of pregnancy (not defined) compared with anti‐diabetic agent (moderate certainty).
1 finding from 1 review
Caesarean section · women with gestational diabetes mellitus
Insulin showed no clear difference in caesarean section compared with anti‐diabetic agent (moderate certainty).
1 finding from 1 review
Development of type 2 diabetes · women with gestational diabetes mellitus
Insulin showed no clear difference in development of type 2 diabetes compared with anti‐diabetic agent (moderate certainty).
1 finding from 1 review
Perineal trauma/tearing ‐ not measured · women with gestational diabetes mellitus
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Postnatal weight retention or return to pre‐pregnancy weight · women with gestational diabetes mellitus
Insulin showed no clear difference in postnatal weight retention or return to pre‐pregnancy weight ‐… compared with anti‐diabetic agent (low certainty).
1 finding from 1 review
Postnatal depression ‐ not measured · women with gestational diabetes mellitus
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Induction of labour · women with gestational diabetes mellitus
Insulin probably leads to higher induction of labour compared with anti‐diabetic agent (moderate certainty).
1 finding from 1 review
Large‐for‐gestational age · Infants of women diagnosed with gestational diabetes
Insulin showed no clear difference in large‐for‐gestational age (birthweight > 90th centile) compared with anti‐diabetic agent (moderate certainty).
1 finding from 1 review
Pre‐eclampsia · pregnant women with pre‐existing diabetes
1 finding from 1 review
Caesarean section · pregnant women with pre‐existing diabetes
1 finding from 1 review
Fetal anomaly · pregnant women with pre‐existing diabetes
1 finding from 1 review