Specificity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review
Summary of findings 1 (no pooled analysis): for the 7 low-prevalence studies specificity ranged from 0.94 (95% CI 0.88 to 0.97) to 0.99 (95% CI 0.98 to 1.00); for the 3 higher-prevalence studies specificity ranged from…
10 studies · 25568 participants
Low
Sensitivity for detection of oral cavity cancer/OPMD · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
1 finding from 1 review
Summary of findings 1 (no pooled analysis): for the 7 studies with low prevalence (<=10%) sensitivity ranged from 0.50 (95% CI 0.07 to 0.93) to 0.99 (95% CI 0.97 to 1.00); for the 3 higher-prevalence studies…
10 studies · 25568 participants
Low
Specificity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, pooled specificity of visual detection for all (initial and advanced) occlusal caries was 75.3% (95% CI 70 to 80) (ungraded).
3 findings from 1 review
Specificity 75.3 [70, 80]
67 studies
GRADE not reported
Specificity 91.2 [88, 94]
12 studies
GRADE not reported
Specificity 77.0 [73, 81]
51 studies
GRADE not reported
PPV for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the positive predictive value of visual detection for advanced occlusal caries was 77.9% at an assumed prevalence of 22.0% (ungraded).
2 findings from 1 review
PPV 77.9
50 studies
GRADE not reported
PPV 30.6
55 studies
GRADE not reported
Sensitivity for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled sensitivity of visual detection for all (initial and advanced) occlusal caries was 49.1% (95% CI 40 to 58) (ungraded).
3 findings from 1 review
Sensitivity 49.1 [40, 58]
12 studies
GRADE not reported
Sensitivity 85.5 [81, 89]
67 studies
GRADE not reported
Sensitivity 85.8 [82, 89]
51 studies
GRADE not reported
Negative LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the negative lr of visual detection for all (initial and advanced) occlusal caries was 0.19 (95% CI 0.15 to 0.25) (ungraded).
3 findings from 1 review
Negative LR 0.19 [0.15, 0.25]
67 studies
GRADE not reported
Negative LR 0.18 [0.14, 0.24]
51 studies
GRADE not reported
Negative LR 0.56 [0.46, 0.68]
12 studies
GRADE not reported
Positive LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the conventional (all-studies) meta-analysis, the positive lr of visual detection for advanced occlusal caries was 7.09 (95% CI 5.6 to 8.9) (ungraded).
3 findings from 1 review
Positive LR 7.09 [5.6, 8.9]
94 studies
GRADE not reported
Positive LR 5.0 [4.3, 5.8]
55 studies
GRADE not reported
Positive LR 12.5 [9.2, 16.9]
50 studies
GRADE not reported
Negative LR for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, the negative lr of visual detection for advanced occlusal caries was 0.58 (95% CI 0.5 to 0.7) (ungraded).
3 findings from 1 review
Negative LR 0.58 [0.5, 0.7]
50 studies
GRADE not reported
Negative LR 0.39 [0.3, 0.5]
94 studies
GRADE not reported
Negative LR 0.29 [0.2, 0.4]
55 studies
GRADE not reported
NPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the Egyptian public health clinic setting, the negative predictive value of visual detection for all (initial and advanced) occlusal caries was 97.4% at an assumed prevalence of 12.9% (ungraded).
2 findings from 1 review
NPV 97.4
51 studies
GRADE not reported
NPV 68.6
12 studies
GRADE not reported
Specificity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled specificity of visual detection for advanced occlusal caries was 96.5% (95% CI 95 to 97) (ungraded).
3 findings from 1 review
Specificity 96.5 [95, 97]
50 studies
GRADE not reported
Specificity 90.9 [88, 93]
94 studies
GRADE not reported
Specificity 84.9 [82, 89]
55 studies
GRADE not reported
NPV for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the negative predictive value of visual detection for advanced occlusal caries was 85.9% at an assumed prevalence of 22.0% (ungraded).
2 findings from 1 review
NPV 85.9
50 studies
GRADE not reported
NPV 97.5
55 studies
GRADE not reported
Positive LR for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Egypt, the positive lr of visual detection for all (initial and advanced) occlusal caries was 3.73 (95% CI 3.1 to 4.4) (ungraded).
3 findings from 1 review
Positive LR 3.73 [3.1, 4.4]
51 studies
GRADE not reported
Positive LR 5.56 [3.7, 8.5]
12 studies
GRADE not reported
Positive LR 3.46 [2.8, 4.3]
67 studies
GRADE not reported
PPV for detecting all (initial and advanced) occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the German private-practice setting, the positive predictive value of visual detection for all (initial and advanced) occlusal caries was 82.0% at an assumed prevalence of 45.0% (ungraded).
2 findings from 1 review
PPV 82.0
12 studies
GRADE not reported
PPV 35.6
51 studies
GRADE not reported
Sensitivity for detecting advanced occlusal caries · Occlusal surfaces of permanent molars (demonstrated in 12-14 year-olds; underlying diagnostic accuracy studies, mostly in vitro)
In the meta-analysis tailored to Germany, pooled sensitivity of visual detection for advanced occlusal caries was 43.7% (95% CI 37 to 51) (ungraded).
3 findings from 1 review
Sensitivity 43.7 [37, 51]
50 studies
GRADE not reported
Sensitivity 64.6 [57, 71]
94 studies
GRADE not reported
Sensitivity 75.1 [70, 81]
55 studies
GRADE not reported
Oral cancer mortality (disease-specific) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
Visual screening (oral visual inspection) by trained health workers showed no clear difference in oral cancer mortality (disease-specific) compared with no screening (low certainty).
2 findings from 1 review
Costs · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
1 finding from 1 review
Harms of screening (false-positive/false-negative outcomes) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
The review found no eligible studies for this question.
1 finding from 1 review
No harms were reported.
0 studies
No studies found
Oral cancer incidence · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
Visual screening (oral visual inspection) by trained health workers showed no clear difference in oral cancer incidence compared with no screening; GRADE not reported.
2 findings from 1 review
Stage at diagnosis (early-stage detection) · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
Visual screening (oral visual inspection) by trained health workers led to lower stage at diagnosis (early-stage detection) compared with no screening; GRADE not reported.
2 findings from 1 review
Quality of life · Apparently healthy adults aged 35 years or older (general population), living in 13 clusters in rural areas of Trivandrum city, Kerala,…
The review found no eligible studies for this question.
1 finding from 1 review