Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Emergency and Critical Care

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 71.4%High 2 · 28.6%

Overall mortality · critically ill participants with ALI and ARDS

INO showed no clear difference in overall mortality compared with control group (moderate certainty).

1 finding from 1 review

Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults 2016 · Cochrane Headline outcomes only
RR 1.04 [0.9, 1.19]
13 studies · 1243 participants
Moderate

Overall mortality at 28 days · critically ill participants with ALI and ARDS

INO showed no clear difference in overall mortality at 28 days compared with control group (moderate certainty).

1 finding from 1 review

Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults 2016 · Cochrane Headline outcomes only
RR 1.08 [0.92, 1.27]
9 studies · 1105 participants
Moderate

Mortality in paediatric population (subgroup) · critically ill participants with ALI and ARDS

INO showed no clear difference in mortality in paediatric population (subgroup) compared with control group (moderate certainty).

1 finding from 1 review

Respiratory effects: PaO2/FiO2 ratio up to 24 hours after initiation of therapy · critically ill participants with ALI and ARDS

INO probably leads to higher paO2/FiO2 up to 24 hours compared with control group (moderate certainty).

1 finding from 1 review

Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults 2016 · Cochrane Headline outcomes only
MD 15.91 [8.25, 23.56]
11 studies · 614 participants
Moderate

Oxygenation index (absolute values) after 24 hours of treatment · critically ill participants with ALI and ARDS

INO showed no clear difference in oxygenation index, 24 hours compared with control group (moderate certainty).

1 finding from 1 review

Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 368 participants
Moderate

Ventilator‐free days up to day 28 · critically ill participants with ALI and ARDS

INO showed no clear difference in ventilation‐free days, up to 30 days compared with control group (high certainty).

1 finding from 1 review

Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 804 participants
High

Incidence of renal impairment · critically ill participants with ALI and ARDS

INO leads to higher renal impairment compared with control group (high certainty).

1 finding from 1 review

Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults 2016 · Cochrane Headline outcomes only
RR 1.59 [1.17, 2.16]
4 studies · 945 participants
High