What do systematic reviews say?

Salivary Actinobacillus level vs Not specified

Salivary Actinobacillus and S. mutans levels were negatively associated.

• Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomes

  Overall
  OR 0.08 [0.01, 0.85]
  1 study
  GRADE not reported

Salivary Actinobacillus level (high) vs Not specified

Salivary F. nucleatum and Actinobacillus levels were not associated with a clear difference.

• Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomes

  Overall
  OR 2.39 [1.00, 5.71]
  1 study
  GRADE not reported

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

It is very uncertain whether mechanical debridement plus local antimicrobial (minocycline… changes bleeding on probing (ratios) compared with mechanical debridement alone (very low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  OR 0.45 [0.14, 1.52]
  1 study · 50 participants
  Very low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  See comment. Killeen 2016 reported no adverse events at follow-up examinations in either study arm. Tonetti 2012 reported that there were no serious adverse events.
  2 studies · 251 participants
  GRADE not reported

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in pocket depth (mm) compared with mechanical debridement alone (low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD -0.10 [-0.59, 0.39]
  1 study · 51 participants
  Low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in clinical attachment level (mm) compared with mechanical debridement alone (low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD 0.10 [-0.42, 0.62]
  1 study · 53 participants
  Low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics

Postoperative systemic antibiotics… showed no clear difference in number of paracetamol (acetaminophen) with codeine tablets required compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.

• Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes

  7 days
  MD -0.31 [-3.94, 3.32]
  1 study · 41 participants
  GRADE not reported

Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo)

• Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis 2022 · Cochrane All outcomes

  12 months
  beta coefficient 10.9 [-12.0, 33.8]
  1 study
  Very low