Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 19 findings · 5 reviews · Headline outcomes only

No studies found 4 · 21.1%GRADE not reported 0 · 0%Very low 8 · 42.1%Low 7 · 36.8%Moderate 0 · 0%High 0 · 0%

IM pethidine vs placebo

Additional analgesia required (epidural, pethidine and Entonox) · women in labour

IM pethidine may leads to lower additional analgesia required (epidural, pethidine and Entonox) compared with placebo (low certainty).

1 finding from 1 review

IM pethidine vs placebo

Maternal satisfaction with analgesia measured during labour (number of women satisfied or very satisfied after 30 minutes) · women in labour

It is very uncertain whether IM pethidine changes maternal satisfaction with analgesia measured during labour (number… compared with placebo (very low certainty).

1 finding from 1 review

IM pethidine vs placebo

Maternal pain score or pain measured in labour (described as good or fair after 1 hour) · women in labour

IM pethidine may leads to higher maternal pain score or pain measured in labour (described as good or… compared with placebo (low certainty).

1 finding from 1 review

IM pethidine vs placebo

Maternal pain score or pain measured in labour (reduction in VAS of at least 40 mm after 30 minutes) · women in labour

IM pethidine may leads to higher maternal pain score or pain measured in labour (reduction in VAS of… compared with placebo (low certainty).

1 finding from 1 review

Paracervical vs intravenous diazepam/pethidine analgesia

Providers' satisfaction with the procedure · women with persistent or prolonged retention of placenta

It is very uncertain whether paracervical block changes providers' satisfaction with the procedure compared with intravenous diazepam/pethidine analgesia (very low certainty).

1 finding from 1 review

Paracervical vs intravenous diazepam/pethidine analgesia

Women's satisfaction with the procedure · women with persistent or prolonged retention of placenta

It is very uncertain whether paracervical block changes women's satisfaction with the procedure compared with intravenous diazepam/pethidine analgesia (very low certainty).

1 finding from 1 review

Tramadol vs pethidine

Additional analgesia required (escape analgesia) · children undergoing surgery

It is very uncertain whether tramadol changes number of patients requiring rescue analgesia (PACU) compared with pethidine (very low certainty).

1 finding from 1 review

Tramadol vs pethidine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

Tramadol showed no clear difference in number of patients with moderate to severe pain (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol vs pethidine

Number of patients with PONV (PACU) · children undergoing surgery

Tramadol showed no clear difference in number of patients with PONV (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Nalbuphine vs pethidine

Number of patients with the need for rescue analgesia (12 hours postoperatively) · children undergoing surgery

Nalbuphine showed no clear difference in number of patients with the need for rescue analgesia (2 hours… compared with pethidine (low certainty).

2 findings from 1 review