Findings

What do systematic reviews say?

9 questions · 9 findings · 3 reviews · Drugs and Alcohol

No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 55.6%Moderate 2 · 22.2%High 1 · 11.1%

Morphine‐positive urines · People with opioid dependence.

The intervention showed no clear difference in morphine‐positive urines (moderate certainty).

1 finding from 1 review

Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence 2014 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1027 participants
Moderate

Morphine‐positive urines · People with opioid dependence.

The intervention showed no clear difference in morphine‐positive urines (moderate certainty).

1 finding from 1 review

Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence 2014 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 729 participants
Moderate

Morphine positive urine or hair analysis objective · patients with opioid dependence

The intervention leads to lower morphine positive urine or hair analysis objective (high certainty).

1 finding from 1 review

Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence 2009 · Cochrane Headline outcomes only
RR 0.66 [0.56, 0.78]
6 studies · 1129 participants
High

Birthweight (g) · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

APGAR score (APGAR score ) · opiate‐dependent pregnant women

The review found no eligible studies for this question.

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adverse events for the mother · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Serious adverse events for the child · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Unacceptability of treatment (dropouts/exclusions during the trial) · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Use of substance · opiate‐dependent pregnant women

Methadone showed no clear difference in use of substance compared with oral slow‐release morphine (low certainty).

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
RR 2.4 [1, 5.77]
1 study · 48 participants
Low