Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

130 questions · 137 findings · 36 reviews · Musculoskeletal

No studies found 6 · 4.4%GRADE not reported 3 · 2.2%Very low 18 · 13.1%Low 55 · 40.1%Moderate 41 · 29.9%High 14 · 10.2%

Mobility training vs control: subgroups with or without cognitive impairments

Level of functioning · older people living in the community with frailty
2 findings from 1 review

Mobility training vs control: subgroups with or without cognitive impairments

Mobility · older people living in the community with frailty
2 findings from 1 review

Autologous myeloablative selective HSCT vs cyclophosphamide

Skin thickness – mRSS Scale 0–51 in which a higher number is worse skin thickening · people with systemic sclerosis

Autologous myeloablative selective HSCT probably leads to higher skin thickness – mRSS Scale 0–51 in which a higher number is worse… compared with cyclophosphamide (moderate certainty).

1 finding from 1 review

Belimumab 10 mg/kg vs placebo

Reduction of at least 4 points in SELENA‐SLEDAI at 52 weeks SELENA‐SLEDAI score, a validated marker of SLE disease activity (range 0 to 105; higher score = worse disease activity) · people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement)

Belimumab 10 mg/kg leads to higher reduction of at least 4 points in SELENA‐SLEDAI at 52 weeks… compared with placebo (high certainty).

1 finding from 1 review