Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

172 questions · 179 findings · 40 reviews · Musculoskeletal · Headline outcomes only

No studies found 21 · 11.7%GRADE not reported 7 · 3.9%Very low 24 · 13.4%Low 68 · 38%Moderate 45 · 25.1%High 14 · 7.8%

High‐dose vs low‐dose colchicine

Participant global assessment of treatment success: proportion with 50% or greater decrease in pain score from baseline ‐ 32 to 36 hours · acute gout

High‐dose showed no clear difference in participant global assessment of treatment success: proportion with… compared with low‐dose colchicine (low certainty).

1 finding from 1 review

High‐dose vs low‐dose colchicine

Total adverse events · acute gout

High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Proportion with 50% or greater decrease in inflammation score from baseline ‐ 32 to 36 hours · acute gout

High‐dose colchicine may leads to higher reduction of inflammation: proportion with 50% or greater decrease… compared with placebo (low certainty).

1 finding from 1 review

High‐dose colchicine vs placebo

Total adverse events · acute gout

High‐dose colchicine may leads to higher total adverse events compared with placebo (low certainty).

1 finding from 1 review