Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

56 questions · 56 findings · 7 reviews · Cystic Fibrosis and Genetic Disorders · Headline outcomes only

No studies found 25 · 44.6%GRADE not reported 0 · 0%Very low 29 · 51.8%Low 0 · 0%Moderate 2 · 3.6%High 0 · 0%

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Acute chest syndrome ( · patients with avascular necrosis in people with sickle cell disease

It is very uncertain whether the intervention changes acute chest syndrome ( (very low certainty).

1 finding from 1 review

Intervention not reported

Pain Acroparaesthesia and Fabry crises · Anderson‐Fabry disease

The review found no eligible studies for this question.

1 finding from 1 review