Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 9 findings · 2 reviews

No studies found 4 · 44.4%GRADE not reported 0 · 0%Very low 1 · 11.1%Low 1 · 11.1%Moderate 3 · 33.3%High 0 · 0%

Guselkumab vs placebo

Proportion of participants cleared or almost cleared ‐ not reported · chronic palmoplantar pustulosis

It is very uncertain whether guselkumab changes proportion of participants cleared or almost cleared compared with placebo (very low certainty).

1 finding from 1 review

Guselkumab vs placebo

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

Guselkumab showed no clear difference in proportion of participants with adverse effects serious or severe… compared with placebo (low certainty).

1 finding from 1 review

Guselkumab vs placebo

Proportion of participants with at least 50% improvement in their quality of life ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Guselkumab vs placebo

Proportion of participants achieving a 50% reduction in disease severity · chronic palmoplantar pustulosis

Guselkumab probably leads to higher proportion of participants achieving a 50% reduction in disease… compared with placebo (moderate certainty).

1 finding from 1 review

Guselkumab vs placebo

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Any systemic treatment vs placebo

Guselkumab · people with chronic plaque psoriasis

Any systemic treatment showed no clear difference in guselkumab compared with placebo (moderate certainty).

2 findings from 1 review