Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 54 findings · 6 reviews · Gynaecology and Fertility

No studies found 0 · 0%GRADE not reported 4 · 7.4%Very low 14 · 25.9%Low 26 · 48.1%Moderate 9 · 16.7%High 1 · 1.9%

Gonadotropins with GnRH agonists vs gonadotropins alone

Multiple pregnancy rate · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH agonists changes multiple pregnancy rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Gonadotropins with GnRH agonists vs gonadotropins alone

Clinical pregnancy rate · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH agonists changes clinical pregnancy rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Live birth rate per couple · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH antagonist changes live birth rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Multiple pregnancy rate · intrauterine insemination (IUI) in women with infertility

Gonadotropins with GnRH antagonist showed no clear difference in multiple pregnancy rate per couple compared with gonadotropins alone (moderate certainty).

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Clinical pregnancy rate · intrauterine insemination (IUI) in women with infertility

Gonadotropins with GnRH antagonist showed no clear difference in clinical pregnancy rate per couple compared with gonadotropins alone (low certainty).

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Ectopic pregnancy rate per couple · intrauterine insemination (IUI) in women with infertility

Gonadotropins with GnRH antagonist showed no clear difference in ectopic pregnancy rate per couple compared with gonadotropins alone (low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Live birth rate per woman · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in live birth per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Mean number of gonadotropin ampoules used per woman · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)
1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Mean number of oocytes retrieved per woman · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)
1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Ovarian Hyperstimulation Syndrome rate per woman ‐ not reported · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… may leads to lower ovarian hyperstimulation syndrome per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (low certainty).

1 finding from 1 review