Femur fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 0.820 [0.618, 1.087]
489106 participants
GRADE not reported
Forearm fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 0.901 [0.751, 1.081]
490889 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The SVMR Maximum Likelihood interval included the null.
3 findings from 1 review
OR 1.363 [0.955, 1.947]
281786 participants
GRADE not reported
OR 1.355 [0.696, 2.635]
281786 participants
GRADE not reported
OR 1.214 [0.746, 1.977]
281786 participants
GRADE not reported
Osteoporosis with pathological fracture · European GWAS participants
The SVMR MR-Egger interval included the null.
3 findings from 1 review
OR 1.097 [0.598, 2.011]
376746 participants
GRADE not reported
OR 1.181 [0.748, 1.866]
376746 participants
GRADE not reported
OR 1.278 [0.921, 1.773]
376746 participants
GRADE not reported
Femur fracture · European GWAS participants
The SVMR MR-Egger interval included the null.
3 findings from 1 review
OR 0.893 [0.678, 1.175]
489106 participants
GRADE not reported
OR 1.137 [0.976, 1.325]
489106 participants
GRADE not reported
OR 1.094 [0.884, 1.354]
489106 participants
GRADE not reported
Lumbar spine and pelvis fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.867 [0.691, 1.087]
490700 participants
GRADE not reported
OR 0.950 [0.808, 1.117]
490700 participants
GRADE not reported
OR 0.994 [0.729, 1.355]
490700 participants
GRADE not reported
Osteoporosis · European GWAS participants
The MVMR MR-Egger interval excluded the null.
1 finding from 1 review
OR 1.343 [1.015, 1.778]
483725 participants
GRADE not reported
Lumbar spine bone mineral density (BMD) · European GWAS participants
The SVMR IVW interval excluded zero.
1 finding from 1 review
Osteoporosis · European GWAS participants
The SVMR Weighted Median interval excluded the null.
3 findings from 1 review
OR 1.260 [1.017, 1.560]
483725 participants
GRADE not reported
OR 1.162 [0.998, 1.353]
483725 participants
GRADE not reported
OR 1.329 [0.991, 1.782]
483725 participants
GRADE not reported
Lumbar spine and pelvis fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.034 [0.769, 1.390]
490700 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.281 [0.640, 2.565]
281786 participants
GRADE not reported
Lumbar spine bone mineral density (BMD) · European GWAS participants
The MVMR IVW interval excluded zero.
1 finding from 1 review
Forearm fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.914 [0.799, 1.046]
490889 participants
GRADE not reported
OR 0.883 [0.738, 1.057]
490889 participants
GRADE not reported
OR 0.920 [0.836, 1.011]
490889 participants
GRADE not reported
Osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.011 [0.876, 1.167]
376746 participants
GRADE not reported
Osteoporosis with pathological fracture · European-ancestry adults
In multivariable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.279, not significant).
2 findings from 1 review
Osteoporosis · European-ancestry adults
In multivariable MR (adjusted for periodontitis), higher genetically predicted dental caries (DMFS) causally increased osteoporosis risk (OR 1.165, moderate evidence).
2 findings from 1 review
Bone mineral density in forearm · European-ancestry adults
Genetically predicted dental caries (DMFS) had no causal effect on forearm BMD.
1 finding from 1 review
Lumbar spine and pelvis fracture · European-ancestry adults
Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of lumbar spine and pelvis (multivariable MR, OR 0.968).
2 findings from 1 review
Forearm fracture · European-ancestry adults
Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of forearm (multivariable MR, OR 0.973).
2 findings from 1 review
Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)
In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence).
2 findings from 1 review