What do systematic reviews say?

G‐CSF vs no treatment or placebo

It is very uncertain whether G‐CSF changes ongoing pregnancy rate per woman randomised compared with no treatment or placebo (very low certainty).

• Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
  RR 1.62 [0.86, 3.08]
  1 study · 150 participants
  Very low

G‐CSF vs no treatment or placebo

It is very uncertain whether G‐CSF changes miscarriage rate per woman randomised compared with no treatment or placebo (very low certainty).

• Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
  Peto OR 0.4 [0.09, 1.77]
  2 studies · 291 participants
  Very low

G‐CSF vs no treatment or placebo

It is very uncertain whether G‐CSF changes clinical pregnancy rate per woman randomised compared with no treatment or placebo (very low certainty).

• Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
  RR 1.65 [1.32, 2.06]
  12 studies · 1050 participants
  Very low

G‐CSF vs no treatment or placebo

G‐CSF showed no clear difference in clinical pregnancy rate ‐ unselected or unstated IVF number compared with no treatment or placebo (low certainty).

• Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
  RR 1.12 [0.75, 1.68]
  2 studies · 291 participants
  Low

G‐CSF vs no treatment or placebo

G‐CSF may leads to higher clinical pregnancy rate ‐ 2 or more IVF failures compared with no treatment or placebo (low certainty).

• Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
  RR 2.1 [1.53, 2.89]
  6 studies · 553 participants
  Low

G‐CSF vs no treatment or placebo

G‐CSF showed no clear difference in clinical pregnancy rate ‐ women with thin endometrium compared with no treatment or placebo (low certainty).

• Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
  RR 1.58 [0.95, 2.63]
  4 studies · 206 participants
  Low

G‐CSF vs no treatment or placebo

The review found no eligible studies for this question.

• Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

G‐CSF vs no treatment or placebo

• Granulocyte‐colony stimulating factor administration for subfertile women undergoing assisted reproduction 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 410 participants
  GRADE not reported