Fresh frozen plasma vs no plasma
Short‐term mortality (up to 30 days) · Neonates, children and adults undergoing cardiovascular surgery
1 finding from 1 review
- no estimate extracted6 studies · 287 participantsVery low
Findings
What do systematic reviews say?
25 questions · 25 findings · 4 reviews
No studies found 8 · 32%GRADE not reported 0 · 0%Very low 8 · 32%Low 3 · 12%Moderate 6 · 24%High 0 · 0%
Fresh frozen plasma vs no plasma
Blood loss in first 24 hours (neonates and paediatric cases) · Neonates, children and adults undergoing cardiovascular surgery
1 finding from 1 review
- no estimate extracted4 studies · 138 participantsLow
Fresh frozen plasma vs no plasma
Red cell transfusion requirement in first 24 hours (neonates and paediatric cases) · Neonates, children and adults undergoing cardiovascular surgery
1 finding from 1 review
- no estimate extracted3 studies · 110 participantsLow
Fresh frozen plasma vs no plasma
Number of participants receiving a red cell transfusion (total) · Neonates, children and adults undergoing cardiovascular surgery
Fresh frozen plasma probably leads to higher number of patients receiving a red cell transfusion compared with no plasma (moderate certainty).
1 finding from 1 review
- OR 2.57 [1.3, 5.08]4 studies · 222 participantsModerate
Fresh frozen plasma vs no plasma
Measurement of prothrombin time within 2 hours of infusion · Neonates, children and adults undergoing cardiovascular surgery
1 finding from 1 review
- no estimate extracted5 studies · 210 participantsModerate
Fresh frozen plasma vs no plasma
Resource use: need for return to theatre · Neonates, children and adults undergoing cardiovascular surgery
Fresh frozen plasma showed no clear difference in resource use: need for return to theatre compared with no plasma (moderate certainty).
1 finding from 1 review
- OR 0.81 [0.26, 2.57]7 studies · 398 participantsModerate
Albumin and fresh frozen plasma vs crystalloid
All‐cause mortality (at end of
Albumin and fresh frozen plasma showed no clear difference in all‐cause mortality (at end of compared with crystalloid (moderate certainty).
1 finding from 1 review
- Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes onlyRR 0.98 [0.92, 1.06]20 studies · 13047 participantsModerate
Albumin and fresh frozen plasma vs crystalloid
All‐cause mortality (within 90 days)
Albumin and fresh frozen plasma showed no clear difference in all‐cause mortality (within 90 days) compared with crystalloid (moderate certainty).
1 finding from 1 review
- Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes onlyRR 0.98 [0.92, 1.04]10 studies · 12492 participantsModerate
Albumin and fresh frozen plasma vs crystalloid
All‐cause mortality (within 30 days)
Albumin and fresh frozen plasma showed no clear difference in all‐cause mortality (within 30 days) compared with crystalloid (moderate certainty).
1 finding from 1 review
- Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes onlyRR 0.99 [0.93, 1.06]10 studies · 12506 participantsModerate
Albumin and fresh frozen plasma vs crystalloid
Transfusion of blood products
It is very uncertain whether albumin and fresh frozen plasma changes transfusion of blood products compared with crystalloid (very low certainty).
1 finding from 1 review
- Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes onlyRR 1.31 [0.95, 1.8]3 studies · 290 participantsVery low
Albumin and fresh frozen plasma vs crystalloid
Renal replacement therapy
Albumin and fresh frozen plasma showed no clear difference in renal replacement therapy compared with crystalloid (low certainty).
1 finding from 1 review
- Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes onlyRR 1.11 [0.96, 1.27]2 studies · 3028 participantsLow
Albumin and fresh frozen plasma vs crystalloid
Adverse events
1 finding from 1 review
- Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedVery low
Fresh frozen plasma vs no treatment
Incidence of hepatic veno‐occlusive disease ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases
It is very uncertain whether summary of findings: Fresh frozen plasma changes incidence of hepatic veno‐occlusive disease ( compared with no treatment (very low certainty).
1 finding from 1 review
- Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes onlyRR 0.66 [0.2, 2.17]2 studies · 383 participantsVery low
Fresh frozen plasma vs no treatment
Overall survival · Patients undergoing stem cell transplant with malignant and non‐malignant diseases
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Fresh frozen plasma vs no treatment
All‐cause mortality at 100 days post‐transplant · Patients undergoing stem cell transplant with malignant and non‐malignant diseases
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Fresh frozen plasma vs no treatment
Mortality attributable to hepatic veno‐occlusive disease ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Fresh frozen plasma vs no treatment
Quality of life · Patients undergoing stem cell transplant with malignant and non‐malignant diseases
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Fresh frozen plasma vs no treatment
Frequency of adverse events ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma
Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use
It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes death or dependence (mRS 4–6) compared with fresh frozen plasma (very low certainty).
1 finding from 1 review
- Haemostatic therapies for stroke due to acute, spontaneous intracerebral haemorrhage 2023 · Cochrane Headline outcomes onlyRR 1.21 [0.76, 1.9]1 study · 37 participantsVery low
Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma
Intracerebral haemorrhage expansion by 24 hours · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use
It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes intracerebral haemorrhage expansion by 24 hours compared with fresh frozen plasma (very low certainty).
1 finding from 1 review
- Haemostatic therapies for stroke due to acute, spontaneous intracerebral haemorrhage 2023 · Cochrane Headline outcomes onlyRR 0.54 [0.23, 1.22]1 study · 36 participantsVery low