Incidence of initial caries around brackets, aesthetic-zone teeth only · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
When only aesthetic-zone teeth (incisors and canines) were considered, two studies reported a significant reduction in initial caries incidence favoring fluoride mouthrinse (ungraded, narrative; no pooled estimate).
1 finding from 1 review
Incidence of proximal (interdental) caries lesions from bitewing radiographs · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Only one included study assessed proximal caries incidence from bitewing radiographs; it was not included in the meta-analysis and no pooled estimate is available (ungraded).
1 finding from 1 review
Incidence of initial enamel caries / white spot lesions adjacent to bracket base (subject level, dichotomized) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Adding a fluoride mouthrinse to daily fluoride toothpaste produced a small reduction in the incidence of initial caries/white spot lesions adjacent to brackets (pooled risk difference -0.07, 95% CI -0.14 to -0.01; 5 studies, 491 subjects), but the authors judged the overall evidence inconclusive (ungraded).
1 finding from 1 review
Side effects or other adverse events · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
No adverse effects were reported in any of the seven included studies (ungraded).
1 finding from 1 review
Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
1 finding from 1 review
Additional SoF Table 3. Adverse effects: current design of the fluoride glass bead inadequate; high attrition partly due to bead breakages ('an improved method of attachment is needed'). 37 participants (1 RCT, Luther…
1 study · 37 participants
Very low
Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether intraoral fluoride-releasing glass bead device attached to the brace changes number of participants with new demineralised lesions (DLs) compared with 250 ppm F (daily) fluoride mouthrinse (very low certainty).
1 finding from 1 review
Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The review found no eligible studies for this question.
1 finding from 1 review
Gingival bleeding (various bleeding indices) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether 1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily changes gingival bleeding index (mean change from baseline) compared with 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily (very low certainty).
1 finding from 1 review
White spot lesion index (mean change from baseline) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether 1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily changes white spot lesion index (mean change from baseline) compared with 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily (very low certainty).
1 finding from 1 review
Plaque index (PI) / oral hygiene · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether 1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily changes visible plaque index (mean change from baseline) compared with 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily (very low certainty).
1 finding from 1 review
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The review found no eligible studies for this question.
1 finding from 1 review
Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The review found no eligible studies for this question.
1 finding from 1 review
Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether patient-used 250 ppm F mouthrinse (100 ppm amine F/150 ppm NaF), daily changes number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo mouthrinse, daily (very low certainty).
1 finding from 1 review