Findings

What do systematic reviews say?

24 questions · 24 findings · 5 reviews

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No studies found 3 · 12.5%GRADE not reported 4 · 16.7%Very low 3 · 12.5%Low 10 · 41.7%Moderate 1 · 4.2%High 3 · 12.5%

Fibrin glue vs Bascom's procedure

Ulcer healing · adults with pilonidal sinus

The review found no eligible studies for this question.

1 finding from 1 review

Fibrin glue for pilonidal sinus disease 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fibrin glue vs Bascom's procedure

Adverse events (seroma or allergic reaction) · adults with pilonidal sinus

The review found no eligible studies for this question.

1 finding from 1 review

Fibrin glue for pilonidal sinus disease 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fibrin glue instillation under skin flaps vs no‐fibrin

Incidence of postoperativeseromaRR · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in incidence of postoperativeseromaRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
RR 1.02 [0.9, 1.16]
18 studies · 1252 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Mean volume of seromaSMD · people with breast and axillary surgery

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 731 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Total volume of drained seromaSMD · people with breast and axillary surgery

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 888 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Number of days for persistent drainageSMD · people with breast and axillary surgery

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 861 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Surgical site infection · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in surgical site infectionRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
RR 1.05 [0.63, 1.77]
13 studies · 1009 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

PostoperativecomplicationsRR · people with breast and axillary surgery

Fibrin glue instillation under skin flaps showed no clear difference in postoperativecomplicationsRR compared with no‐fibrin (low certainty).

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
RR 1.13 [0.63, 2.04]
11 studies · 981 participants
Low

Fibrin glue instillation under skin flaps vs no‐fibrin

Length of hospital stay (theoretical) · people with breast and axillary surgery

1 finding from 1 review

Fibrin glue instillation under skin flaps to prevent seroma‐related morbidity following breast and axillary surgery 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 364 participants
Low

Fibrin glue vs Conventional fistulotomy / seton

Recurrence simple fistula · patients with anorectal fistula

Fibrin glue showed no clear difference in recurrence simple fistula compared with conventional fistulotomy / seton (moderate certainty).

1 finding from 1 review

Surgical intervention for anorectal fistula 2010 · Cochrane Headline outcomes only
OR 15 [0.6, 376.7]
1 study · 13 participants
Moderate

Fibrin glue vs Conventional fistulotomy / seton

Incontinence simple fistula · patients with anorectal fistula

1 finding from 1 review

Surgical intervention for anorectal fistula 2010 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
High

Limberg flap plus fibrin glue vs off‐midline closure (Limberg flap)

Ulcer healing · Men with pilonidal sinus

1 finding from 1 review

Fibrin glue for pilonidal sinus disease 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 132 participants
Very low

Limberg flap plus fibrin glue vs off‐midline closure (Limberg flap)

Adverse event (seroma) · Men with pilonidal sinus

It is very uncertain whether limberg flap plus fibrin glue changes adverse event (seroma) compared with limberg flap (very low certainty).

1 finding from 1 review

Fibrin glue for pilonidal sinus disease 2017 · Cochrane Headline outcomes only
RR 0.27 [0.05, 1.63]
2 studies · 164 participants
Very low

Karydakis flap plus fibrin glue vs Karydakis flap and drain

Ulcer healing · Men with pilonidal sinus

The review found no eligible studies for this question.

1 finding from 1 review

Fibrin glue for pilonidal sinus disease 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Karydakis flap plus fibrin glue vs Karydakis flap and drain

Adverse event (seroma) · Men with pilonidal sinus

It is very uncertain whether karydakis flap plus fibrin glue changes adverse event (seroma) compared with karydakis flap and drain (very low certainty).

1 finding from 1 review

Fibrin glue for pilonidal sinus disease 2017 · Cochrane Headline outcomes only
RR 3 [0.67, 13.46]
1 study · 50 participants
Very low

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Radiographic assessment: coronal bone volume (cm3) · Patients aged 7 to 16 years with unilateral or bilateral cleft lip and palate (alveolar cleft)

Traditional iliac bone graft plus fibrin glue led to higher radiographic assessment: coronal bone volume (cm3) compared with traditional iliac bone graft alone; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
At least 3 months
MD 42.62 [20.99, 64.25]
1 study · 27 participants
GRADE not reported

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Wound infection · Patients aged 7 to 16 years with unilateral or bilateral cleft lip and palate (alveolar cleft)

Traditional iliac bone graft plus fibrin glue showed no clear difference in postoperative complication: wound infection compared with traditional iliac bone graft alone; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
At least 3 months
RR 3.23 [0.14, 100]
1 study · 27 participants
GRADE not reported

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Radiographic assessment: coronal bone density (Hounsfield units) · Patients aged 7 to 16 years with unilateral or bilateral cleft lip and palate (alveolar cleft)

Traditional iliac bone graft plus fibrin glue led to higher radiographic assessment: coronal bone density (Hounsfield units) compared with traditional iliac bone graft alone; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
At least 3 months
MD 150.89 [3.45, 298.33]
1 study · 27 participants
GRADE not reported

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Wound dehiscence · Patients aged 7 to 16 years with unilateral or bilateral cleft lip and palate (alveolar cleft)

Traditional iliac bone graft plus fibrin glue showed no clear difference in postoperative complication: wound dehiscence compared with traditional iliac bone graft alone; GRADE not reported.

1 finding from 1 review

Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate 2011 · Cochrane All outcomes
At least 3 months
RR 0.36 [0.04, 3.03]
1 study · 27 participants
GRADE not reported

Advancement flap vs Fibrin glue with Flap repair

Recurrence · patients with anorectal fistula

Advancement flap leads to lower recurrence compared with fibrin glue with Flap repair (high certainty).

1 finding from 1 review

Surgical intervention for anorectal fistula 2010 · Cochrane Headline outcomes only
OR 0.29 [0.09, 0.92]
1 study · 58 participants
High