Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

11 questions · 15 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 6.7%Low 9 · 60%Moderate 5 · 33.3%High 0 · 0%

Fibrates vs control

Stroke, myocardial infarction, or vascular death · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates probably leads to lower composite outcome of non‐fatal stroke, non‐fatal myocardial… compared with control (moderate certainty).

1 finding from 1 review

Fibrates vs control

Fatal or nonfatal stroke · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in stroke (ischaemic or haemorrhagic, non‐fatal or fatal) during the… compared with control (low certainty).

2 findings from 1 review

Fibrates vs control

Death from any cause during the treatment and scheduled · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in death from any cause during the treatment and scheduled compared with control (low certainty).

2 findings from 1 review

Fibrates vs control

Deaths due to vascular events · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in death from vascular causes during the treatment and scheduled compared with control (low certainty).

2 findings from 1 review

Fibrates vs control

Fatal or nonfatal myocardial infarction · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates probably leads to lower myocardial infarction (non‐fatal or fatal) during the treatment and… compared with control (moderate certainty).

2 findings from 1 review

Fibrates vs control

Composite outcome of non‐fatal stroke, non‐fatal myocardial infarction, and vascular death without clofibrate · People with previous clinical manifestations of cardiovascular disease, transient ischaemic attack, or stroke

Fibrates showed no clear difference in composite outcome of non‐fatal stroke, non‐fatal myocardial… compared with control (low certainty).

1 finding from 1 review

Intervention not reported

Combined CVD death, non‐fatal MI, or non‐fatal stroke · patients in primary prevention of cardiovascular disease events

The intervention probably leads to lower combined CVD death, non‐fatal MI, or non‐fatal stroke (moderate certainty).

1 finding from 1 review

Intervention not reported

Combined coronary heart disease death or non‐fatal MI · patients in primary prevention of cardiovascular disease events

The intervention probably leads to lower combined coronary heart disease death or non‐fatal MI (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall mortality · patients in primary prevention of cardiovascular disease events

The intervention showed no clear difference in overall mortality (low certainty).

1 finding from 1 review

Intervention not reported

Non‐CVD mortality · patients in primary prevention of cardiovascular disease events

The intervention showed no clear difference in non‐CVD mortality (low certainty).

1 finding from 1 review

Intervention not reported

Discontinuation of therapy due to adverse effects · patients in primary prevention of cardiovascular disease events

It is very uncertain whether the intervention changes discontinuation of therapy due to adverse effects (very low certainty).

1 finding from 1 review