Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 25 findings · 4 reviews · Acute Respiratory Infections

No studies found 4 · 16%GRADE not reported 0 · 0%Very low 5 · 20%Low 9 · 36%Moderate 7 · 28%High 0 · 0%

Epinephrine vs placebo

Admissions at enrollment or < 24 hours (outpatients only) · patients with acute viral bronchiolitis

Epinephrine probably leads to lower admissions at enrollment or < 24 hours (outpatients only) compared with placebo (moderate certainty).

1 finding from 1 review

Epinephrine vs steroids

Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with steroid (moderate certainty).

1 finding from 1 review

Epinephrine vs placebo

Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with placebo (low certainty).

1 finding from 1 review

Epinephrine vs salbutamol/albuterol

Admissions at enrollment or < 24 hours (outpatients only) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions at enrollment or < 24 hours (outpatients only) compared with salbutamol/albuterol (moderate certainty).

1 finding from 1 review

Epinephrine vs salbutamol/albuterol

Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with salbutamol/albuterol (moderate certainty).

1 finding from 1 review

Epinephrine vs steroids

Admissions (outpatients) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions (outpatients only) compared with steroid (moderate certainty).

1 finding from 1 review

Epinephrine and steroid vs placebo

Admissions at enrollment or < 24 hours (outpatients only) · patients with acute viral bronchiolitis

Epinephrine and steroid showed no clear difference in admissions at enrollment or < 24 hours (outpatients only) compared with placebo (low certainty).

1 finding from 1 review

Epinephrine and steroid vs placebo

Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis

Epinephrine and steroid may leads to lower admissions overall up to 7 days (outpatients only) compared with placebo (low certainty).

1 finding from 1 review

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

Length of hospital stay · children up to 12 months old with acute bronchiolitis

It is very uncertain whether magnesium sulphate + epinephrine changes duration of hospital stay compared with no treatment or normal saline + epinephrine (very low certainty).

1 finding from 1 review

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

Clinical severity score (CSS) (RDAI score; range 0 to 17; higher = poorer outcomes) measured at 0 to 24 hoursafter treatment · children up to 12 months old with acute bronchiolitis

It is very uncertain whether magnesium sulphate + epinephrine changes clinical severity score (CSS) (RDAI score; range 0 to 17; higher =… compared with no treatment or normal saline + epinephrine (very low certainty).

1 finding from 1 review

Magnesium sulphate + epinephrine vs no treatment or normal saline + epinephrine

Clinical severity score (CSS) (RDAI score; range 0 to 17; higher = poorer outcomes) measured 25 to 48 hoursafter treatment · children up to 12 months old with acute bronchiolitis

It is very uncertain whether magnesium sulphate + epinephrine changes clinical severity score (CSS) (RDAI score; range 0 to 17; higher =… compared with no treatment or normal saline + epinephrine (very low certainty).

1 finding from 1 review

Any glucocorticoid vs epinephrine

Change in croup score. · children with croup
4 findings from 1 review
Show 1 more finding

Any glucocorticoid vs epinephrine

Return visits or (re)admissions or both · children with croup

Any glucocorticoid showed no clear difference in return visits or (re)admissions or both compared with epinephrine (low certainty).

1 finding from 1 review