Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

78 questions · 83 findings · 13 reviews · Headline outcomes only

No studies found 12 · 14.5%GRADE not reported 1 · 1.2%Very low 23 · 27.7%Low 28 · 33.7%Moderate 15 · 18.1%High 4 · 4.8%

Epinephrine vs epinephrine and any second endoscopic method

Recurrent and persistent bleeding overall rates with or without second‐look endoscopy Rebleeding (persistent or recurrent bleeding) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower recurrent and persistent bleeding overall rates with or without… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Surgery rate Number requiring emergency surgery · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower surgery rate Number requiring emergency surgery compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Mortality rate Number of deaths (30‐day mortality or in‐hospital mortality) · patients with high‐risk bleeding ulcers

Epinephrine probably leads to lower mortality rate Number of deaths (30‐day mortality or in‐hospital… compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs epinephrine and any second endoscopic method

Adverse effects of endoscopy therapy Adverse effects · patients with high‐risk bleeding ulcers

Epinephrine probably leads to higher adverse effects of endoscopy therapy Adverse effects compared with epinephrine and any second endoscopic method (moderate certainty).

1 finding from 1 review

Epinephrine vs norepinephrine‐dobutamine

All‐cause short‐term mortality: 28 days · adults with cardiogenic shock

It is very uncertain whether epinephrine changes all‐cause short‐term mortality: 28 days compared with norepinephrine‐dobutamine (very low certainty).

1 finding from 1 review

Epinephrine vs norepinephrine

Total mortalitya · hypotensive shock

Epinephrine showed no clear difference in total mortalitya compared with norepinephrine (low certainty).

1 finding from 1 review

Epinephrine vs placebo

Admissions at enrollment or < 24 hours (outpatients only) · patients with acute viral bronchiolitis

Epinephrine probably leads to lower admissions at enrollment or < 24 hours (outpatients only) compared with placebo (moderate certainty).

1 finding from 1 review

Epinephrine vs steroids

Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with steroid (moderate certainty).

1 finding from 1 review

Epinephrine vs placebo

Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with placebo (low certainty).

1 finding from 1 review

Epinephrine vs salbutamol/albuterol

Admissions at enrollment or < 24 hours (outpatients only) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions at enrollment or < 24 hours (outpatients only) compared with salbutamol/albuterol (moderate certainty).

1 finding from 1 review

Epinephrine vs salbutamol/albuterol

Admissions overall up to 7 days (outpatients only) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with salbutamol/albuterol (moderate certainty).

1 finding from 1 review

Epinephrine vs steroids

Admissions (outpatients) · patients with acute viral bronchiolitis

Epinephrine showed no clear difference in admissions (outpatients only) compared with steroid (moderate certainty).

1 finding from 1 review