Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 32 findings · 10 reviews · Pregnancy and Childbirth

No studies found 1 · 3.1%GRADE not reported 3 · 9.4%Very low 4 · 12.5%Low 12 · 37.5%Moderate 7 · 21.9%High 5 · 15.6%

Early initiation of epidural analgesia vs Late initiation

Caesarean section · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in caesarean section compared with late initiation (high certainty).

1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Instrumental delivery · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in instrumental delivery compared with late initiation (high certainty).

1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Apgar score less than 7 at 5 minutes · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in apgar score <7 at 5 min compared with late initiation (high certainty).

1 finding from 1 review

Non‐pharmacological interventions for fear of childbirth (tocophobia) vs usual care

Epidural analgesia during labour · women with fear of childbirth (tocophobia)

Non‐pharmacological interventions for fear of childbirth (tocophobia) showed no clear difference in epidural analgesia during labour compared with usual care (low certainty).

1 finding from 1 review

Case notes vs control

Epidural analgesia during labour · pregnant women from the time of their first antenatal visit to the end of the puerperium

Case notes showed no clear difference in epidural analgesia used in labour compared with control (low certainty).

1 finding from 1 review

Combined spinal‐epidural vs high‐dose spinal

Number of women requiring supplemental intra‐operative analgesia at any time after CSE or spinal anaesthetic insertion · women undergoing caesarean section

It is very uncertain whether combined spinal‐epidural changes number of women requiring supplemental intra‐operative analgesia at… compared with high‐dose spinal (very low certainty).

1 finding from 1 review

Combined spinal‐epidural vs low‐dose spinal

Number of women requiring supplemental intra‐operative analgesia at any time after CSE or spinal anaesthetic insertion · women undergoing caesarean section

Combined spinal‐epidural showed no clear difference in number of women requiring supplemental intra‐operative analgesia at… compared with low‐dose spinal (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Midwife continuity models vs other models of care

Regional analgesia (epidural/spinal) · childbearing women and their infants (all) (important/secondary outcomes)

It is very uncertain whether summary of findings table ‐ Midwife continuity of care models changes regional analgesia (epidural/spinal) compared with other models of care (very low certainty).

1 finding from 1 review

IM pethidine vs placebo

Additional analgesia required (epidural, pethidine and Entonox) · women in labour

IM pethidine may leads to lower additional analgesia required (epidural, pethidine and Entonox) compared with placebo (low certainty).

1 finding from 1 review