Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

211 questions · 214 findings · 24 reviews · Headline outcomes only

No studies found 44 · 20.6%GRADE not reported 12 · 5.6%Very low 91 · 42.5%Low 61 · 28.5%Moderate 5 · 2.3%High 1 · 0.5%

Early enteral nutrition vs delayed enteral nutrition

Feed intolerance or gastrointestinal complications (as defined by the authors) · critically ill adult patients

It is very uncertain whether early enteral nutrition changes feed intolerance or gastrointestinal complications (as defined by… compared with delayed enteral nutrition (very low certainty).

1 finding from 1 review

Late parenteral nutrition vs early parenteral nutrition

Healthcare‐associated blood stream infection · critically ill term and late preterm infants

Late parenteral nutrition showed no clear difference in healthcare‐associated blood stream infection compared with early parenteral nutrition (low certainty).

1 finding from 1 review

Early enteral nutrition with supplemental parenteral nutrition (SPN) vs delayed enteral nutrition with SPN

Mortality (timing of outcome measurement unclear) · critically ill adult patients

It is very uncertain whether early enteral nutrition with supplemental parenteral nutrition (SPN) changes mortality (timing of outcome measurement unclear) compared with delayed enteral nutrition with SPN (very low certainty).

1 finding from 1 review

Early enteral nutrition with supplemental parenteral nutrition (SPN) vs delayed enteral nutrition with SPN

Feed intolerance or gastrointestinal complications (as defined by the authors) · critically ill adult patients

The review found no eligible studies for this question.

1 finding from 1 review