Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 6 reviews · Breast Cancer

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 25%Low 6 · 25%Moderate 7 · 29.2%High 5 · 20.8%

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Treatment adherence (defined as dose delay) ( · adjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in treatment adherence (defined as dose delay) ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

Taxane followed by anthracyclines vs anthracyclines followed by taxane

Treatment adherence (defined as dose reduction) ( · neoadjuvant therapy for early breast cancer

Taxane followed by anthracyclines showed no clear difference in treatment adherence (defined as dose reduction) ( compared with anthracyclines followed by taxane (moderate certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Treatment‐related mortality · women with early poor prognosis breast cancer

High‐dose chemotherapy leads to higher treatment‐related mortality compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

Early shoulder mobilising exercises vs delayed shoulder mobilising exercises

Lymphoedema ‐ medium term · patients at risk for secondary upper limb lymphoedema after breast cancer treatment

It is very uncertain whether early shoulder mobilising exercises changes lymphoedema ‐ medium term compared with delayed shoulder mobilising exercises (very low certainty).

1 finding from 1 review