Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

41 questions · 51 findings · 8 reviews · Periodontology

No studies found 15 · 29.4%GRADE not reported 22 · 43.1%Very low 12 · 23.5%Low 0 · 0%Moderate 2 · 3.9%High 0 · 0%

Periodontal treatment (scaling and root planing, alone or with antimicrobials) vs Alternative (less intensive) periodontal treatment, alone or with placebo

Adverse effects of therapy · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

The review found no eligible studies for this question.

1 finding from 1 review

Autologous platelet concentrates (APC) + enamel matrix derivative (EMD) vs EMD (enamel matrix derivative) alone

Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + enamel matrix derivative… changes change in radiographic bone defect filling (RBF) (%) compared with EMD (enamel matrix derivative) alone (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in radiographic bone defect filling (RBF) (%) compared with OFD (open flap debridement) alone (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone

Change in radiographic bone defect filling (RBF) (%) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

The review found no eligible studies for this question.

1 finding from 1 review

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Adverse effects of therapy · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Any adverse effect related to aPDT · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
1 finding from 1 review

Interdental brushing plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)
2 findings from 2 reviews · compare the 2 reviews

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT

Any adverse effect related to aPDT · Adults (> 18 years) with peri-implant mucositis, receiving active treatment

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Any adverse effect related to aPDT · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
1 finding from 1 review

Flossing plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review

Oral irrigation plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in conjunction with mechanical oral hygiene procedures vs Placebo/control mouthrinse, or no mouthrinse (mechanical oral hygiene alone); controls pooled (protocol's separate comparisons versus mechanical oral hygiene alone and versus placebo/control merged)

Other adverse effects (taste disturbance, oral mucosal effects, burning sensation) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…
1 finding from 1 review

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

Side effects · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)
1 finding from 1 review

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Adverse effects (e.g. thermal sensitivity, over-eruption, TMJ symptoms, poor aesthetics, reduced oral hygiene) · Adults with chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Adverse effects (e.g. thermal sensitivity, over-eruption, TMJ symptoms, poor aesthetics, reduced oral hygiene) · Adults with chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Change in probing pocket depth (PPD) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

It is very uncertain whether autologous platelet concentrates (APC) + open flap debridement (OFD) changes change in probing depth (PD) (mm) compared with OFD (open flap debridement) alone (very low certainty).

1 finding from 1 review