Measures of air pollution exposure ( · healthy individuals and those with a pre‐existing health condition
1 finding from 1 review
no estimate extracted
173 participants
Very low
Health Service Utilisation · healthy individuals and those with a pre‐existing health condition
1 finding from 1 review
no estimate extracted
2948 participants
Very low
Respiratory exacerbations · healthy individuals and those with a pre‐existing health condition
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · healthy individuals and those with a pre‐existing health condition
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious adverse events · healthy individuals and those with a pre‐existing health condition
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Successful treatment of exacerbation: number of participants cured. Outcome assessed on day 42 · bronchiectasis
It is very uncertain whether oral + inhaled dual therapy changes successful treatment of exacerbation: number of participants cured.… compared with oral monotherapy (very low certainty).
1 finding from 1 review
Successful treatment of exacerbation: number of participants with P aeruginosa eradication. Outcome assessed on day 21 · bronchiectasis
It is very uncertain whether oral + inhaled dual therapy changes successful treatment of exacerbation: number of participants with P… compared with oral monotherapy (very low certainty).
1 finding from 1 review
Serious adverse events. Outcome assessed on day 42 · bronchiectasis
It is very uncertain whether oral + inhaled dual therapy changes serious adverse events. Outcome assessed on day 42 compared with oral monotherapy (very low certainty).
1 finding from 1 review
Relapse · bronchiectasis
It is very uncertain whether oral + inhaled dual therapy changes treatment response: relapse (day 42). Outcome assessed on day 42 compared with oral monotherapy (very low certainty).
1 finding from 1 review
Microbiological response: eradicated. Outcome assessed on day 21 · bronchiectasis
It is very uncertain whether oral + inhaled dual therapy changes microbiological response: eradicated. Outcome assessed on day 21 compared with oral monotherapy (very low certainty).
1 finding from 1 review
Hospital admissions · bronchiectasis
1 finding from 1 review
Death · bronchiectasis
1 finding from 1 review
Quality of life · bronchiectasis
1 finding from 1 review
Intervention not reported
ACQ responders at 6 months ‐ TRIPLE vs DUAL№ of participants: 7881(5 RCTs)
The intervention may leads to higher ACQ responders at 6 months ‐ TRIPLE vs DUAL№ of participants: 7881(5… (low certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 12 months ‐ TRIPLE vs DUAL№ of participants: 6204(4 RCTs)
It is very uncertain whether the intervention changes ACQ responders at 12 months ‐ TRIPLE vs DUAL№ of participants:… (very low certainty).
1 finding from 1 review
Intervention not reported
All cause SAEs ‐ TRIPLE vs DUAL№ of participants: 8192(6 RCTs)
The intervention showed no clear difference in all cause SAEs ‐ TRIPLE vs DUAL№ of participants: 8192(6 RCTs) (high certainty).
1 finding from 1 review
Intervention not reported
Severe exacerbations ‐ TRIPLE vs DUAL№ of participants: 2540(2 RCTs)
The intervention showed no clear difference in severe exacerbations ‐ TRIPLE vs DUAL№ of participants: 2540(2 RCTs) (moderate certainty).
1 finding from 1 review
Intervention not reported
Asthma‐related SAEs ‐ TRIPLE vs DUAL№ of participants: 8192(6 RCTs)
The intervention showed no clear difference in asthma‐related SAEs ‐ TRIPLE vs DUAL№ of participants: 8192(6 RCTs) (high certainty).
1 finding from 1 review
Intervention not reported
All cause AEs ‐ TRIPLE vs DUAL№ of participants: 8192(6 RCTs)
The intervention leads to lower all cause AEs ‐ TRIPLE vs DUAL№ of participants: 8192(6 RCTs) (high certainty).
1 finding from 1 review
Intervention not reported
Dropouts due to adverse event ‐ TRIPLE vs DUAL№ of participants: 8223(5 RCTs)
The intervention showed no clear difference in dropouts due to adverse event ‐ TRIPLE vs DUAL№ of participants:… (moderate certainty).
1 finding from 1 review