Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

107 questions · 107 findings · 10 reviews · Infectious Diseases

No studies found 2 · 1.9%GRADE not reported 16 · 15%Very low 14 · 13.1%Low 30 · 28%Moderate 34 · 31.8%High 11 · 10.3%

Moxifloxacin‐containing 4‐month ATT regimens vs standard 6‐month ATT regimen

Treatment failure · adults with drug‐sensitive pulmonary tuberculosis

Moxifloxacin‐containing 4‐month ATT regimens showed no clear difference in treatment failure compared with standard 6‐month ATT regimen (moderate certainty).

1 finding from 1 review

Moxifloxacin‐containing 4‐month ATT regimens vs standard 6‐month ATT regimen

Acquired drug resistance · adults with drug‐sensitive pulmonary tuberculosis

Moxifloxacin‐containing 4‐month ATT regimens showed no clear difference in acquired drug resistance compared with standard 6‐month ATT regimen (low certainty).

1 finding from 1 review

Gatifloxacin‐containing 4‐month ATT regimens vs standard 6‐month ATT regimen

Treatment failure · adults with drug‐sensitive pulmonary tuberculosis

Gatifloxacin‐containing 4‐month ATT regimens showed no clear difference in treatment failure compared with standard 6‐month ATT regimens (moderate certainty).

1 finding from 1 review

Gatifloxacin‐containing 4‐month ATT regimens vs standard 6‐month ATT regimen

Acquired drug resistance · adults with drug‐sensitive pulmonary tuberculosis

It is very uncertain whether gatifloxacin‐containing 4‐month ATT regimens changes acquired drug resistance compared with standard 6‐month ATT regimens (very low certainty).

1 finding from 1 review

Linezolid vs no linezolid

Number of women who completed treatment ‐ total · drug‐resistant pulmonary tuberculosis

It is very uncertain whether linezolid changes treatment completed compared with no linezolid (very low certainty).

1 finding from 1 review

Linezolid vs no linezolid

Antituberculous treatment discontinuationj · drug‐resistant pulmonary tuberculosis

It is very uncertain whether linezolid changes antituberculous treatment discontinuationj compared with no linezolid (very low certainty).

1 finding from 1 review

Intervention not reported

Clinical failure 1 to 14 days after end of treatment · adults and children with amoebic colitis

It is very uncertain whether the intervention changes clinical failure 1 to 14 days after end of treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Parasitological failure 1 to 14 days after end of treatment Method: stool microscopy demonstrating E histolytica cysts or trophozoites · adults and children with amoebic colitis

The intervention may leads to lower parasitological failure 1 to 14 days after end of treatment Method:… (low certainty).

1 finding from 1 review