Findings

What do systematic reviews say?

32 questions · 32 findings · 3 reviews · Developmental, Psychosocial and Learning Problems · Headline outcomes only

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No studies found 9 · 28.1%GRADE not reported 0 · 0%Very low 12 · 37.5%Low 8 · 25%Moderate 2 · 6.3%High 1 · 3.1%

Closest answers

The findings closest to your search, judged one by one by TypeSafe's Jev model.

Direct match · question page
- Parent‐mediated intervention vs treatment · Expressive language (number of (different) target words)
  Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 12 participants
  Very low
Direct match · question page
- Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone · Expressive language (number of words; standard scores; MLUw; NDW; IPSyn; frequency of unique targets; % target talk)
  Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low
Direct match · question page
- Comparison 1: donepezil vs placebo · Cognitive abilities (Severe Impairment Battery; SIB)
  Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 165 participants
  Low
Direct match · question page
- Parent‐mediated intervention vs treatment · Receptive language (total language; standard scores)
  Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 15 participants
  Very low
Direct match · question page
- Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone · Receptive language (total language; standard scores)
  Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low

Parent‐mediated intervention vs treatment

Expressive language (number of (different) target words) · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Parental stress · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Changes in parental behaviour/responsivity · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Socialisation · children with Down syndrome aged between birth and six years

The review found no eligible studies for this question.

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Language attrition · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Adherence · children with Down syndrome aged between birth and six years

The review found no eligible studies for this question.

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parent‐mediated intervention vs treatment

Receptive language (total language; standard scores) · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15 participants
Very low

Parent‐mediated intervention vs treatment

Parental stress · children with Down syndrome aged between birth and six years

The review found no eligible studies for this question.

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Parent‐mediated intervention vs treatment

Changes in parental behaviour/responsivity · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 27 participants
Very low

Parent‐mediated intervention vs treatment

Socialisation · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15 participants
Very low

Parent‐mediated intervention vs treatment

Language attrition · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 27 participants
Very low

Parent‐mediated intervention vs treatment

Adherence · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Expressive language (number of words; standard scores; MLUw; NDW; IPSyn; frequency of unique targets; % target talk) · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Parent‐ and clinician‐mediated intervention vs clinician‐mediated intervention alone

Receptive language (total language; standard scores) · children with Down syndrome aged between birth and six years

1 finding from 1 review

Parent‐mediated interventions for promoting communication and language development in young children with Down syndrome 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Donepezil vs placebo

Cognitive abilities (Severe Impairment Battery; SIB) · people with Down syndrome

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 165 participants
Low

Memantine vs placebo

Carer stress · people with Down syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Memantine vs placebo

Institutional/home care · people with Down syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Memantine vs placebo

Death · people with Down syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Donepezil vs placebo

Behavioural problems: overall · people with Down syndrome

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 157 participants
Low

Donepezil vs placebo

Adverse events · people with Down syndrome

Comparison 1: donepezil may leads to lower adverse events compared with placebo (low certainty).

1 finding from 1 review

Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
OR 0.32 [0.16, 0.62]
4 studies · 192 participants
Low