Cochrane · systematic review · CD011546
Pharmacological interventions for cognitive decline in people with Down syndrome
Livingstone, N, Hanratty, J, McShane, R, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
6
No studies
6
Included studies
NR
No studies 6 · 50%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison 1: donepezil versus placebo
Population: people with Down syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive abilities (Severe Impairment Battery; SIB) Comparison 1: donepezil vs placebo | no estimate extracted | 3 studies · 165 participants | Low Downgraded: imprecision, inconsistency |
Behavioural problems (various scales) Comparison 1: donepezil vs placebo | no estimate extracted | 3 studies · 157 participants | Low Downgraded: imprecision, inconsistency |
Adverse events Comparison 1: donepezil vs placebo | OR 0.32 [0.16, 0.62] | 4 studies · 192 participants | Low Downgraded: imprecision, inconsistency |
Carer stress Comparison 1: donepezil vs placebo | no estimate extracted | NR | No studies |
Institutional/home care Comparison 1: donepezil vs placebo | no estimate extracted | NR | No studies |
Death Comparison 1: donepezil vs placebo | no estimate extracted | NR | No studies |
Comparison 2: memantine versus placebo
Population: people with Down syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Cognitive abilities (various scales) Comparison 2: memantine vs placebo | no estimate extracted | 2 studies · 184 participants | Low Downgraded: imprecision, inconsistency |
Behavioural problems (various scales) Comparison 2: memantine vs placebo | no estimate extracted | 2 studies · 186 participants | Low Downgraded: imprecision, inconsistency |
Adverse events Comparison 2: memantine vs placebo | OR 0.45 [0.18, 1.17] | 2 studies · 211 participants | Low Downgraded: imprecision, inconsistency |
Carer stress Comparison 2: memantine vs placebo | no estimate extracted | NR | No studies |
Institutional/home care Comparison 2: memantine vs placebo | no estimate extracted | NR | No studies |
Death Comparison 2: memantine vs placebo | no estimate extracted | NR | No studies |