Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Pain, Palliative and Supportive Care

No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 0 · 0%High 0 · 0%

Participants with ≥ 1 vomiting episode · adults receiving intravenous opioids

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in vomiting (≥1 episode) compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
RR 1.18 [0.26, 5.32]
3 studies · 527 participants
Low

Nausea · adults receiving intravenous opioids

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in nausea (≥1 episode) compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
RR 0.55 [0.15, 2.03]
2 studies · 336 participants
Low

Adverse events · adults receiving intravenous opioids

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
RR 2.34 [0.47, 11.61]
3 studies · 527 participants
Low

Number of vomiting episodes · adults receiving intravenous opioids

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Nausea severity · adults receiving intravenous opioids

1 finding from 1 review

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 191 participants
Low

Use of rescue medication · adults receiving intravenous opioids

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in rescue medication compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
RR 1.86 [0.17, 20.16]
3 studies · 527 participants
Low